Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past to Help Discover Long-Acting Oral Drugs in the Future

Paul W. Smith, Fabio Zuccotto, Robert H. Bates, Maria Santos Martinez-Martinez, Kevin D. Read, Caroline Peet, Ola Epemolu

Research output: Contribution to journalArticle

7 Citations (Scopus)
144 Downloads (Pure)

Abstract

β-Lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research, none of the currently approved drugs in this class combine oral activity with long duration of action. Recent developments suggest that new β-lactam antibiotics with such a profile would have utility in the treatment of tuberculosis. Consequently, the historical β-lactam pharmacokinetic data have been compiled and analyzed to identify possible directions and drug discovery strategies aimed toward new β-lactam antibiotics with this profile.

Original languageEnglish
Pages (from-to)1439-1447
Number of pages9
JournalACS Infectious Diseases
Volume4
Issue number10
Early online date24 Aug 2018
DOIs
Publication statusPublished - 12 Oct 2018

Keywords

  • carbapenem
  • cephalosporin
  • M. tuberculosis
  • penicillin
  • pharmacokinetics
  • β-lactam

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