Projects per year
Abstract
β-Lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research, none of the currently approved drugs in this class combine oral activity with long duration of action. Recent developments suggest that new β-lactam antibiotics with such a profile would have utility in the treatment of tuberculosis. Consequently, the historical β-lactam pharmacokinetic data have been compiled and analyzed to identify possible directions and drug discovery strategies aimed toward new β-lactam antibiotics with this profile.
Original language | English |
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Pages (from-to) | 1439-1447 |
Number of pages | 9 |
Journal | ACS Infectious Diseases |
Volume | 4 |
Issue number | 10 |
Early online date | 24 Aug 2018 |
DOIs | |
Publication status | Published - 12 Oct 2018 |
Keywords
- carbapenem
- cephalosporin
- M. tuberculosis
- penicillin
- pharmacokinetics
- β-lactam
ASJC Scopus subject areas
- Infectious Diseases
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Wellcome Centre for Anti-Infectives Research
Cook, S. (Investigator), De Rycker, M. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator), Pawlowic, M. C. (Investigator), Read, K. (Investigator), Wyatt, P. (Investigator) & Wyllie, S. (Investigator)
1/04/17 → 31/03/25
Project: Research
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A Centre of Excellence for Lead Optimisation for Diseases of the Developing World (Joint funding by Wellcome & Gates)
Gilbert, I. (Investigator), Gray, D. (Investigator), Read, K. (Investigator) & Wyatt, P. (Investigator)
1/07/13 → 31/10/18
Project: Research