TY - JOUR
T1 - Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers
AU - Lopez-Charcas, Osbaldo
AU - Pukkanasut, Piyasuda
AU - Velu, Sadanandan E.
AU - Brackenbury, William J.
AU - Hales, Tim G.
AU - Besson, Pierre
AU - Gomora, Juan Carlos
AU - Roger, Sébastien
N1 - Authors declare no conflict of Interest. This consortium was supported by a grant from LE STUDIUM, Loire Valley Institute for Advanced Studies, Orléans & Tours, France (“Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of epithelial cancers”, Grant number Y17C3 ). Research performed in S.R. lab was supported by the University of Tours , the “Ligue Nationale Contre le Cancer—Interrégion Grand-Ouest”, the Région Centre-Val de Loire, the “Association CANCEN”. S.R. was recipient of a prize “Prix Ruban Rose Avenir 2017” from the Charity “Ruban Rose”. O.L.-C. was recipient of a funding from the “Fondation pour la Recherche Médicale ( FRM )” ( SPF201909009198 ). WJB acknowledges funding from Cancer Research UK ( A25922 ) and Breast Cancer Now ( 2015NovPhD572 ). J.C.G. research has been supported by CONACYT -México grant A1-S-19171 and PAPIIT-DGAPA-UNAM grant IN209820 . S.E.V. acknowledges the funding from US National Institutes of Health ( R21CA226491 and R21DE028349 ). TGH acknowledges the Stewart family for their generous support of research investigating ion channels in colon cancer. Figures 1 and 2 were created using BioRender.com.
PY - 2021/4/23
Y1 - 2021/4/23
N2 - Voltage-gated sodium (NaV) channels, initially characterized in excitable cells, have been shown to be aberrantly expressed in non-excitable cancer tissues and cells from epithelial origins such as in breast, lung, prostate, colon, and cervix, whereas they are not expressed in cognate non-cancer tissues. Their activity was demonstrated to promote aggressive and invasive potencies of cancer cells, both in vitro and in vivo, whereas their deregulated expression in cancer tissues has been associated with metastatic progression and cancer-related death. This review proposes NaV channels as pharmacological targets for anticancer treatments providing opportunities for repurposing existing NaV-inhibitors or developing new pharmacological and nutritional interventions.
AB - Voltage-gated sodium (NaV) channels, initially characterized in excitable cells, have been shown to be aberrantly expressed in non-excitable cancer tissues and cells from epithelial origins such as in breast, lung, prostate, colon, and cervix, whereas they are not expressed in cognate non-cancer tissues. Their activity was demonstrated to promote aggressive and invasive potencies of cancer cells, both in vitro and in vivo, whereas their deregulated expression in cancer tissues has been associated with metastatic progression and cancer-related death. This review proposes NaV channels as pharmacological targets for anticancer treatments providing opportunities for repurposing existing NaV-inhibitors or developing new pharmacological and nutritional interventions.
KW - Cancer
KW - Cell Biology
UR - http://www.scopus.com/inward/record.url?scp=85102650272&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2021.102270
DO - 10.1016/j.isci.2021.102270
M3 - Review article
C2 - 33817575
AN - SCOPUS:85102650272
SN - 2589-0042
VL - 24
SP - 102270
JO - iScience
JF - iScience
IS - 4
M1 - 102270
ER -
