Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers

Osbaldo Lopez-Charcas, Piyasuda Pukkanasut, Sadanandan E. Velu, William J. Brackenbury, Tim G. Hales, Pierre Besson, Juan Carlos Gomora, Sébastien Roger (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

10 Downloads (Pure)

Abstract

Voltage-gated sodium (NaV) channels, initially characterized in excitable cells, have been shown to be aberrantly expressed in non-excitable cancer tissues and cells from epithelial origins such as in breast, lung, prostate, colon, and cervix, whereas they are not expressed in cognate non-cancer tissues. Their activity was demonstrated to promote aggressive and invasive potencies of cancer cells, both in vitro and in vivo, whereas their deregulated expression in cancer tissues has been associated with metastatic progression and cancer-related death. This review proposes NaV channels as pharmacological targets for anticancer treatments providing opportunities for repurposing existing NaV-inhibitors or developing new pharmacological and nutritional interventions.

Original languageEnglish
Article number102270
Pages (from-to)102270
Number of pages26
JournaliScience
Volume24
Issue number4
Early online date6 Mar 2021
DOIs
Publication statusPublished - 23 Apr 2021

Keywords

  • Cancer
  • Cell Biology

Fingerprint

Dive into the research topics of 'Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers'. Together they form a unique fingerprint.

Cite this