Pharmacological space

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


A precise mapping of the biological target space is essential in drug discovery for many reasons. First, it enables to properly describe targets of existing drugs and clinical candidates and therefore estimate the druggability of major target families. Second, it permits to orient early drug discovery towards previously uncharted target space (e.g. protein-protein interactions, epigenetic targets) with the hope of discovering selective and safe drug candidates. Last, it provides an ideal framework to better understand molecular reasons for promiscuity and polyphamacology.

Original languageEnglish
Title of host publicationThe practice of medicinal chemistry
EditorsCamille Wermuth, David Aldous, Pierre Raboisson, Didier Rognan
PublisherAcademic Press
Number of pages14
ISBN (Print)9780124172050
Publication statusPublished - 2015


  • Chemical space
  • Druggable genome
  • Target space

ASJC Scopus subject areas

  • General Medicine


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