Pharmacological space

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A precise mapping of the biological target space is essential in drug discovery for many reasons. First, it enables to properly describe targets of existing drugs and clinical candidates and therefore estimate the druggability of major target families. Second, it permits to orient early drug discovery towards previously uncharted target space (e.g. protein-protein interactions, epigenetic targets) with the hope of discovering selective and safe drug candidates. Last, it provides an ideal framework to better understand molecular reasons for promiscuity and polyphamacology.

Original languageEnglish
Title of host publicationThe practice of medicinal chemistry
EditorsCamille Wermuth, David Aldous, Pierre Raboisson, Didier Rognan
PublisherAcademic Press
Pages395-408
Number of pages14
Edition4th
ISBN (Print)9780124172050
DOIs
Publication statusPublished - 2015

Keywords

  • Chemical space
  • Druggable genome
  • Target space

Fingerprint Dive into the research topics of 'Pharmacological space'. Together they form a unique fingerprint.

  • Cite this

    Hopkins, A. L. (2015). Pharmacological space. In C. Wermuth, D. Aldous, P. Raboisson, & D. Rognan (Eds.), The practice of medicinal chemistry (4th ed., pp. 395-408). Academic Press. https://doi.org/10.1016/B978-0-12-417205-0.00016-X