Phase I/II trial of batimastat, a matrix metalloproteinase inhibitor, in patients with malignant ascites

Simon L. Parsons, Susan A. Watson, Robert J. C. Steele

    Research output: Contribution to journalArticlepeer-review

    74 Citations (Scopus)

    Abstract

    Matrix metalloproteinases have been shown to be important in tumour invasion and metastasis, and the use of matrix metalloproteinase inhibitors in animal models has suggested that these agents may be useful in the control of malignant disease. This article reports the results of an early clinical trial of batimastat, one of the first generation of metalloproteinase inhibitors, in patients with malignant ascites. The drug was well absorbed via the intraperitoneal route and associated with few side-effects. Furthermore, a response to treatment was seen in about half the evaluable patients with advanced malignant disease. The results suggest that further research on the use of matrix metalloproteinase inhibitors in patients with malignant disease is worthwhile.
    Original languageEnglish
    Pages (from-to)526-531
    Number of pages6
    JournalEuropean Journal of Surgical Oncology
    Volume23
    Issue number6
    DOIs
    Publication statusPublished - Dec 1997

    Keywords

    • Aged
    • Antineoplastic Agents
    • Ascites
    • Gastrointestinal Neoplasms
    • Humans
    • Infusions, Parenteral
    • Metalloendopeptidases
    • Middle Aged
    • Phenylalanine
    • Protease Inhibitors
    • Thiophenes
    • Treatment Outcome

    Fingerprint Dive into the research topics of 'Phase I/II trial of batimastat, a matrix metalloproteinase inhibitor, in patients with malignant ascites'. Together they form a unique fingerprint.

    Cite this