Phenotype standardisation of angioedema in the head and neck region caused by agents acting on the angiotensin system

Mia Wadelius (Lead / Corresponding author), Sara E. Marshall, Gunilla Islander, Leif Nordang, Malgorzata Karawajczyk, Qun-Ying Yue, Ingrid Terreehorst, Ekaterina V. Baranova, Svante Hugosson, Karin Sköldefors, Munir Pirmohamed, Anke-Hilse Maitland van der Zee, Ana Alfirevic, Pär Hallberg, Colin N. A. Palmer

    Research output: Contribution to journalReview article

    13 Citations (Scopus)

    Abstract

    Angioedema is a potentially life-threatening adverse reaction to angiotensin converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicentre recruitment of patients are needed. To reduce patient heterogeneity, we have standardised the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.
    Original languageEnglish
    Pages (from-to)477-481
    JournalClinical Pharmacology & Therapeutics
    Volume96
    Issue number4
    Early online date24 Jun 2014
    DOIs
    Publication statusPublished - Oct 2014

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    Keywords

    • Drug-Related Side Effects and Adverse Reactions
    • Angioedema
    • Renin-Angiotensin System
    • Angiotensin-Converting Enzyme Inhibitors
    • Angiotensin Receptor Antagonists
    • Phenotype
    • Reference Standards

    Cite this

    Wadelius, M., Marshall, S. E., Islander, G., Nordang, L., Karawajczyk, M., Yue, Q-Y., Terreehorst, I., Baranova, E. V., Hugosson, S., Sköldefors, K., Pirmohamed, M., Maitland van der Zee, A-H., Alfirevic, A., Hallberg, P., & Palmer, C. N. A. (2014). Phenotype standardisation of angioedema in the head and neck region caused by agents acting on the angiotensin system. Clinical Pharmacology & Therapeutics, 96(4), 477-481. https://doi.org/10.1038/clpt.2014.138