Phenotype standardization for statin-induced myotoxicity

A. Alfirevic; D. Neely; J. Armitage; H. Chinoy; R. G. Cooper; R. Laaksonen; D. F. Carr; K. M. Bloch; J. Fahy; A. Hanson; Q. Y. Yue; M. Wadelius; A. H. Maitland-van Der Zee; D. Voora; B. M. Psaty; C. N. A. Palmer; M. Pirmohamed

doi:10.1038/clpt.2014.121

Phenotype standardization for statin-induced myotoxicity

A. Alfirevic (Lead / Corresponding author), D. Neely, J. Armitage, H. Chinoy, R. G. Cooper, R. Laaksonen, D. F. Carr, K. M. Bloch, J. Fahy, A. Hanson, Q. Y. Yue, M. Wadelius, A. H. Maitland-van Der Zee, D. Voora, B. M. Psaty, C. N. A. Palmer, M. Pirmohamed

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Abstract

Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.

Original language	English
Pages (from-to)	470-476
Number of pages	7
Journal	Clinical Pharmacology & Therapeutics
Volume	96
Issue number	4
Early online date	4 Jun 2014
DOIs	https://doi.org/10.1038/clpt.2014.121
Publication status	Published - Oct 2014

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/clpt.2014.121

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Cite this

Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., Carr, D. F., Bloch, K. M., Fahy, J., Hanson, A., Yue, Q. Y., Wadelius, M., Maitland-van Der Zee, A. H., Voora, D., Psaty, B. M., Palmer, C. N. A., & Pirmohamed, M. (2014). Phenotype standardization for statin-induced myotoxicity. Clinical Pharmacology & Therapeutics, 96(4), 470-476. https://doi.org/10.1038/clpt.2014.121

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abstract = "Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.",

author = "A. Alfirevic and D. Neely and J. Armitage and H. Chinoy and Cooper, {R. G.} and R. Laaksonen and Carr, {D. F.} and Bloch, {K. M.} and J. Fahy and A. Hanson and Yue, {Q. Y.} and M. Wadelius and {Maitland-van Der Zee}, {A. H.} and D. Voora and Psaty, {B. M.} and Palmer, {C. N. A.} and M. Pirmohamed",

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Alfirevic, A, Neely, D, Armitage, J, Chinoy, H, Cooper, RG, Laaksonen, R, Carr, DF, Bloch, KM, Fahy, J, Hanson, A, Yue, QY, Wadelius, M, Maitland-van Der Zee, AH, Voora, D, Psaty, BM, Palmer, CNA & Pirmohamed, M 2014, 'Phenotype standardization for statin-induced myotoxicity', Clinical Pharmacology & Therapeutics, vol. 96, no. 4, pp. 470-476. https://doi.org/10.1038/clpt.2014.121

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T1 - Phenotype standardization for statin-induced myotoxicity

AU - Alfirevic, A.

AU - Neely, D.

AU - Armitage, J.

AU - Chinoy, H.

AU - Cooper, R. G.

AU - Laaksonen, R.

AU - Carr, D. F.

AU - Bloch, K. M.

AU - Fahy, J.

AU - Hanson, A.

AU - Yue, Q. Y.

AU - Wadelius, M.

AU - Maitland-van Der Zee, A. H.

AU - Voora, D.

AU - Psaty, B. M.

AU - Palmer, C. N. A.

AU - Pirmohamed, M.

PY - 2014/10

Y1 - 2014/10

N2 - Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.

AB - Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.

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DO - 10.1038/clpt.2014.121

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SP - 470

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JO - Clinical Pharmacology & Therapeutics

JF - Clinical Pharmacology & Therapeutics

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ER -

Phenotype standardization for statin-induced myotoxicity

Abstract

ASJC Scopus subject areas

UN SDGs

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PREDICTION-ADR: Personalisation of tREatment In Cardiovascular Disease Through Next Generation Sequencing - Adverse Drug Reactions (Joint with University of Uppsala, University of Liverpool and University of Utrecht)

Palmer, Colin

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Phenotype standardization for statin-induced myotoxicity

Abstract

ASJC Scopus subject areas

UN SDGs

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PREDICTION-ADR: Personalisation of tREatment In Cardiovascular Disease Through Next Generation Sequencing - Adverse Drug Reactions (Joint with University of Uppsala, University of Liverpool and University of Utrecht)

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Palmer, Colin

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