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Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.
|Number of pages||7|
|Journal||Clinical Pharmacology & Therapeutics|
|Early online date||4 Jun 2014|
|Publication status||Published - Oct 2014|
ASJC Scopus subject areas
- Pharmacology (medical)
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- 1 Finished
- Population Health and Genomics - Professor (Teaching and Research) of Pharmacogenomics