Phosphatases in SMAD regulation

D.L. Bruce, G.P. Sapkota

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)

    Abstract

    SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase.
    Original languageEnglish
    Pages (from-to)1897-1905
    Number of pages9
    JournalFEBS Letters
    Volume586
    Issue number14
    DOIs
    Publication statusPublished - 4 Jul 2012

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