Phosphatases in SMAD regulation

D.L. Bruce; G.P. Sapkota

doi:10.1016/j.febslet.2012.02.001

Phosphatases in SMAD regulation

D.L. Bruce, G.P. Sapkota

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69 Citations (Scopus)

Abstract

SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase.

Original language	English
Pages (from-to)	1897-1905
Number of pages	9
Journal	FEBS Letters
Volume	586
Issue number	14
DOIs	https://doi.org/10.1016/j.febslet.2012.02.001
Publication status	Published - 4 Jul 2012

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title = "Phosphatases in SMAD regulation",

abstract = "SMAD transcription factors are key mediators of the transforming growth factor-beta (TGF{\ss}) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGF{\ss}/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase.",

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AB - SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase.

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Phosphatases in SMAD regulation

Abstract

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