Phospho-regulation and Function of ULK1-ATG13 During the Cell Cycle

Zhiyuan Li, Xin Zhang (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

Abstract

Although it has been reported that some autophagy-related proteins could regulate the cell cycle, the function of ULK1-ATG13, the only protein kinase complex in macroautophagy/autophagy, remains unclear. We recently found that mitotic ULK1 and ATG13 are both substrates of the key cell cycle regulator CDK1-CCNB/cyclin B. CDK1-induced ULK1-ATG13 phosphorylation promotes mitotic autophagy and cell cycle progression. Moreover, ULK1 and ATG13 double-knockout significantly inhibits cell cycle progression and tumor cell proliferation in vitro and in vivo. These findings bridge the mutual regulation between autophagic and mitotic key kinases and provide a theoretical basis for autophagy- and cell division-related diseases based on combination therapy.

Original languageEnglish
Pages (from-to)1054-1056
Number of pages3
JournalAutophagy
Volume17
Issue number4
Early online date5 Mar 2021
DOIs
Publication statusPublished - 2021

Keywords

  • ATG13
  • CDK1
  • ULK1
  • autophagy
  • mitosis

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