Abstract
Although it has been reported that some autophagy-related proteins could regulate the cell cycle, the function of ULK1-ATG13, the only protein kinase complex in macroautophagy/autophagy, remains unclear. We recently found that mitotic ULK1 and ATG13 are both substrates of the key cell cycle regulator CDK1-CCNB/cyclin B. CDK1-induced ULK1-ATG13 phosphorylation promotes mitotic autophagy and cell cycle progression. Moreover, ULK1 and ATG13 double-knockout significantly inhibits cell cycle progression and tumor cell proliferation in vitro and in vivo. These findings bridge the mutual regulation between autophagic and mitotic key kinases and provide a theoretical basis for autophagy- and cell division-related diseases based on combination therapy.
Original language | English |
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Pages (from-to) | 1054-1056 |
Number of pages | 3 |
Journal | Autophagy |
Volume | 17 |
Issue number | 4 |
Early online date | 5 Mar 2021 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- ATG13
- CDK1
- ULK1
- autophagy
- mitosis
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology