Phospho-regulation and Function of ULK1-ATG13 During the Cell Cycle

Zhiyuan Li; Xin Zhang

doi:10.1080/15548627.2021.1898750

Phospho-regulation and Function of ULK1-ATG13 During the Cell Cycle

Zhiyuan Li, Xin Zhang (Lead / Corresponding author)

MRC PPU

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Abstract

Although it has been reported that some autophagy-related proteins could regulate the cell cycle, the function of ULK1-ATG13, the only protein kinase complex in macroautophagy/autophagy, remains unclear. We recently found that mitotic ULK1 and ATG13 are both substrates of the key cell cycle regulator CDK1-CCNB/cyclin B. CDK1-induced ULK1-ATG13 phosphorylation promotes mitotic autophagy and cell cycle progression. Moreover, ULK1 and ATG13 double-knockout significantly inhibits cell cycle progression and tumor cell proliferation in vitro and in vivo. These findings bridge the mutual regulation between autophagic and mitotic key kinases and provide a theoretical basis for autophagy- and cell division-related diseases based on combination therapy.

Original language	English
Pages (from-to)	1054-1056
Number of pages	3
Journal	Autophagy
Volume	17
Issue number	4
Early online date	5 Mar 2021
DOIs	https://doi.org/10.1080/15548627.2021.1898750
Publication status	Published - 2021

Keywords

ATG13
CDK1
ULK1
autophagy
mitosis

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1080/15548627.2021.1898750

Author Accepted ManuscriptAccepted author manuscript, 612 KBLicence: CC BY-NC

Cite this

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title = "Phospho-regulation and Function of ULK1-ATG13 During the Cell Cycle",

abstract = "Although it has been reported that some autophagy-related proteins could regulate the cell cycle, the function of ULK1-ATG13, the only protein kinase complex in macroautophagy/autophagy, remains unclear. We recently found that mitotic ULK1 and ATG13 are both substrates of the key cell cycle regulator CDK1-CCNB/cyclin B. CDK1-induced ULK1-ATG13 phosphorylation promotes mitotic autophagy and cell cycle progression. Moreover, ULK1 and ATG13 double-knockout significantly inhibits cell cycle progression and tumor cell proliferation in vitro and in vivo. These findings bridge the mutual regulation between autophagic and mitotic key kinases and provide a theoretical basis for autophagy- and cell division-related diseases based on combination therapy.",

keywords = "ATG13, CDK1, ULK1, autophagy, mitosis",

author = "Zhiyuan Li and Xin Zhang",

note = "Funding for this research was provided by: National Key Research and Development Program of China (2016YFA0400900) National Natural Science Foundation of China (31900508) National Key Research and Development Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2021",

doi = "10.1080/15548627.2021.1898750",

language = "English",

volume = "17",

pages = "1054--1056",

journal = "Autophagy",

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TY - JOUR

T1 - Phospho-regulation and Function of ULK1-ATG13 During the Cell Cycle

AU - Li, Zhiyuan

AU - Zhang, Xin

N1 - Funding for this research was provided by: National Key Research and Development Program of China (2016YFA0400900) National Natural Science Foundation of China (31900508) National Key Research and Development Publisher Copyright: © 2021 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2021

Y1 - 2021

N2 - Although it has been reported that some autophagy-related proteins could regulate the cell cycle, the function of ULK1-ATG13, the only protein kinase complex in macroautophagy/autophagy, remains unclear. We recently found that mitotic ULK1 and ATG13 are both substrates of the key cell cycle regulator CDK1-CCNB/cyclin B. CDK1-induced ULK1-ATG13 phosphorylation promotes mitotic autophagy and cell cycle progression. Moreover, ULK1 and ATG13 double-knockout significantly inhibits cell cycle progression and tumor cell proliferation in vitro and in vivo. These findings bridge the mutual regulation between autophagic and mitotic key kinases and provide a theoretical basis for autophagy- and cell division-related diseases based on combination therapy.

AB - Although it has been reported that some autophagy-related proteins could regulate the cell cycle, the function of ULK1-ATG13, the only protein kinase complex in macroautophagy/autophagy, remains unclear. We recently found that mitotic ULK1 and ATG13 are both substrates of the key cell cycle regulator CDK1-CCNB/cyclin B. CDK1-induced ULK1-ATG13 phosphorylation promotes mitotic autophagy and cell cycle progression. Moreover, ULK1 and ATG13 double-knockout significantly inhibits cell cycle progression and tumor cell proliferation in vitro and in vivo. These findings bridge the mutual regulation between autophagic and mitotic key kinases and provide a theoretical basis for autophagy- and cell division-related diseases based on combination therapy.

KW - ATG13

KW - CDK1

KW - ULK1

KW - autophagy

KW - mitosis

UR - https://www.scopus.com/pages/publications/85102875280

U2 - 10.1080/15548627.2021.1898750

DO - 10.1080/15548627.2021.1898750

M3 - Article

C2 - 33666137

SN - 1554-8627

VL - 17

SP - 1054

EP - 1056

JO - Autophagy

JF - Autophagy

IS - 4

ER -

Phospho-regulation and Function of ULK1-ATG13 During the Cell Cycle

Abstract

Keywords

ASJC Scopus subject areas

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