Phosphoinositide 3-kinase signalling pathways

Doreen Ann Cantrell (Lead / Corresponding author)

    Research output: Contribution to journalComment/debatepeer-review

    457 Citations (Scopus)

    Abstract

    Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3′-OH position of the inositol ring of inositol phospholipids, producing three lipid products: PtdIns(3)P, PtdIns(3,4)P2 and PtdIns(3,4,5)P3. These lipids bind to the pleckstrin homology (PH) domains of proteins and control the activity and subcellular localisation of a diverse array of signal transduction molecules. Three major classes of signalling molecule are regulated by binding of D-3 phosphoinositides to PH domains: guanine-nucleotide-exchange proteins for Rho family GTPases, the TEC family tyrosine kinases such as BTK and ITK in B and T lymphocytes, respectively, and the AGC superfamily of serine/threonine protein kinases. These molecules are activated by a variety of extracellular stimuli and have been implicated in a wide range of cellular processes, including cell cycle progression, cell growth, cell motility, cell adhesion and cell survival.

    Original languageEnglish
    Pages (from-to)1439-1445
    Number of pages7
    JournalJournal of Cell Science
    Volume114
    Issue number8
    Publication statusPublished - 15 Apr 2001

    Keywords

    • PH domains
    • Phosphoinositide 3-kinase
    • Protein kinase B
    • Rac-1
    • Tec kinases

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