Phosphoinositide 3-kinases in T lymphocyte activation

Stephen G. Ward, Doreen A. Cantrell (Lead / Corresponding author)

    Research output: Contribution to journalReview article

    83 Citations (Scopus)

    Abstract

    Biochemical experiments have established that the metabolism of inositol phospholipids by phosphoinositide 3-kinases (PI3Ks) and lipid-phosphatases is triggered by many receptors that control T lymphocyte function, including antigen-receptors, costimulatory molecules, cytokines and chemokines. Novel effectors of PI3K have been identified in the immune system and shown to be important in the control of lymphocyte activation. Moreover, key lipid-phosphatases have been identified that act to terminate or modulate PI3K signalling in cells of the immune system.

    Original languageEnglish
    Pages (from-to)332-338
    Number of pages7
    JournalCurrent Opinion in Immunology
    Volume13
    Issue number3
    DOIs
    Publication statusPublished - 1 Jun 2001

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