Phosphoinositide 3-kinases in T lymphocyte activation

TY - JOUR

T1 - Phosphoinositide 3-kinases in T lymphocyte activation

AU - Ward, Stephen G.

AU - Cantrell, Doreen A.

PY - 2001/6/1

Y1 - 2001/6/1

N2 - Biochemical experiments have established that the metabolism of inositol phospholipids by phosphoinositide 3-kinases (PI3Ks) and lipid-phosphatases is triggered by many receptors that control T lymphocyte function, including antigen-receptors, costimulatory molecules, cytokines and chemokines. Novel effectors of PI3K have been identified in the immune system and shown to be important in the control of lymphocyte activation. Moreover, key lipid-phosphatases have been identified that act to terminate or modulate PI3K signalling in cells of the immune system.

AB - Biochemical experiments have established that the metabolism of inositol phospholipids by phosphoinositide 3-kinases (PI3Ks) and lipid-phosphatases is triggered by many receptors that control T lymphocyte function, including antigen-receptors, costimulatory molecules, cytokines and chemokines. Novel effectors of PI3K have been identified in the immune system and shown to be important in the control of lymphocyte activation. Moreover, key lipid-phosphatases have been identified that act to terminate or modulate PI3K signalling in cells of the immune system.

UR - https://www.scopus.com/pages/publications/0035367805

U2 - 10.1016/S0952-7915(00)00223-5

DO - 10.1016/S0952-7915(00)00223-5

M3 - Review article

C2 - 11406365

AN - SCOPUS:0035367805

SN - 0952-7915

VL - 13

SP - 332

EP - 338

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 3

ER -