Phospholemman and the cardiac sodium pump: Protein kinase C, take a bow

William Fuller, Michael J. Shattock

    Research output: Contribution to journalEditorialpeer-review

    5 Citations (Scopus)

    Abstract

    An extract of the first 100 words of the full text is provided, because this article has no abstract. In excitable tissues, the activity of the plasmalemmal sodium/potassium ATPase (Na/K pump) is vital for the maintenance of normal electrical activity and ion gradients. In cardiac muscle, the transsarcolemmal sodium (Na) gradient established by the Na/K activity is essential not only for generating the rapid upstroke of the action potential but also for driving a number of ion exchange and transport processes that are crucial for normal cellular function, excitation contraction coupling, ion homeostasis and the control of cell volume. These Na-dependent membrane transporters include those responsible for the regulation of other ions (such as the sodium calcium exchanger (NCX), . . .
    Original languageEnglish
    Pages (from-to)1290-1292
    Number of pages3
    JournalCirculation Research
    Volume99
    Issue number12
    DOIs
    Publication statusPublished - Dec 2006

    Keywords

    • Phospholemman
    • FXYD
    • Protein kinase C
    • Na/K pump

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