Phospholemman and the cardiac sodium pump: Protein kinase C, take a bow

William Fuller, Michael J. Shattock

    Research output: Contribution to journalEditorialpeer-review

    6 Citations (Scopus)


    An extract of the first 100 words of the full text is provided, because this article has no abstract. In excitable tissues, the activity of the plasmalemmal sodium/potassium ATPase (Na/K pump) is vital for the maintenance of normal electrical activity and ion gradients. In cardiac muscle, the transsarcolemmal sodium (Na) gradient established by the Na/K activity is essential not only for generating the rapid upstroke of the action potential but also for driving a number of ion exchange and transport processes that are crucial for normal cellular function, excitation contraction coupling, ion homeostasis and the control of cell volume. These Na-dependent membrane transporters include those responsible for the regulation of other ions (such as the sodium calcium exchanger (NCX), . . .
    Original languageEnglish
    Pages (from-to)1290-1292
    Number of pages3
    JournalCirculation Research
    Issue number12
    Publication statusPublished - Dec 2006


    • Phospholemman
    • FXYD
    • Protein kinase C
    • Na/K pump


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