Phospholemman and the cardiac sodium pump: Protein kinase C, take a bow

William Fuller; Michael J. Shattock

doi:10.1161/01.RES.0000253090.54488.81

Phospholemman and the cardiac sodium pump: Protein kinase C, take a bow

William Fuller
, Michael J. Shattock

Research output: Contribution to journal › Editorial › peer-review

6 Citations (Scopus)

Abstract

An extract of the first 100 words of the full text is provided, because this article has no abstract. In excitable tissues, the activity of the plasmalemmal sodium/potassium ATPase (Na/K pump) is vital for the maintenance of normal electrical activity and ion gradients. In cardiac muscle, the transsarcolemmal sodium (Na) gradient established by the Na/K activity is essential not only for generating the rapid upstroke of the action potential but also for driving a number of ion exchange and transport processes that are crucial for normal cellular function, excitation contraction coupling, ion homeostasis and the control of cell volume. These Na-dependent membrane transporters include those responsible for the regulation of other ions (such as the sodium calcium exchanger (NCX), . . .

Original language	English
Pages (from-to)	1290-1292
Number of pages	3
Journal	Circulation Research
Volume	99
Issue number	12
DOIs	https://doi.org/10.1161/01.RES.0000253090.54488.81
Publication status	Published - Dec 2006

Keywords

Phospholemman
FXYD
Protein kinase C
Na/K pump

Access to Document

10.1161/01.RES.0000253090.54488.81

Cite this

@article{44ef759d82a84935a527e722fd32abe4,

title = "Phospholemman and the cardiac sodium pump: Protein kinase C, take a bow",

abstract = "An extract of the first 100 words of the full text is provided, because this article has no abstract. In excitable tissues, the activity of the plasmalemmal sodium/potassium ATPase (Na/K pump) is vital for the maintenance of normal electrical activity and ion gradients. In cardiac muscle, the transsarcolemmal sodium (Na) gradient established by the Na/K activity is essential not only for generating the rapid upstroke of the action potential but also for driving a number of ion exchange and transport processes that are crucial for normal cellular function, excitation contraction coupling, ion homeostasis and the control of cell volume. These Na-dependent membrane transporters include those responsible for the regulation of other ions (such as the sodium calcium exchanger (NCX), . . .",

keywords = "Phospholemman, FXYD, Protein kinase C, Na/K pump",

author = "William Fuller and Shattock, \{Michael J.\}",

note = "dc.description.sponsorship: British Heart Foundation (Intermediate Fellowship FS/03/052) Research Councils UK (Academic Felowship) ",

year = "2006",

month = dec,

doi = "10.1161/01.RES.0000253090.54488.81",

language = "English",

volume = "99",

pages = "1290--1292",

journal = "Circulation Research",

issn = "0009-7330",

publisher = "Lippincott Williams and Wilkins",

number = "12",

}

TY - JOUR

T1 - Phospholemman and the cardiac sodium pump

T2 - Protein kinase C, take a bow

AU - Fuller, William

AU - Shattock, Michael J.

N1 - dc.description.sponsorship: British Heart Foundation (Intermediate Fellowship FS/03/052) Research Councils UK (Academic Felowship)

PY - 2006/12

Y1 - 2006/12

N2 - An extract of the first 100 words of the full text is provided, because this article has no abstract. In excitable tissues, the activity of the plasmalemmal sodium/potassium ATPase (Na/K pump) is vital for the maintenance of normal electrical activity and ion gradients. In cardiac muscle, the transsarcolemmal sodium (Na) gradient established by the Na/K activity is essential not only for generating the rapid upstroke of the action potential but also for driving a number of ion exchange and transport processes that are crucial for normal cellular function, excitation contraction coupling, ion homeostasis and the control of cell volume. These Na-dependent membrane transporters include those responsible for the regulation of other ions (such as the sodium calcium exchanger (NCX), . . .

AB - An extract of the first 100 words of the full text is provided, because this article has no abstract. In excitable tissues, the activity of the plasmalemmal sodium/potassium ATPase (Na/K pump) is vital for the maintenance of normal electrical activity and ion gradients. In cardiac muscle, the transsarcolemmal sodium (Na) gradient established by the Na/K activity is essential not only for generating the rapid upstroke of the action potential but also for driving a number of ion exchange and transport processes that are crucial for normal cellular function, excitation contraction coupling, ion homeostasis and the control of cell volume. These Na-dependent membrane transporters include those responsible for the regulation of other ions (such as the sodium calcium exchanger (NCX), . . .

KW - Phospholemman

KW - FXYD

KW - Protein kinase C

KW - Na/K pump

U2 - 10.1161/01.RES.0000253090.54488.81

DO - 10.1161/01.RES.0000253090.54488.81

M3 - Editorial

C2 - 17158344

SN - 0009-7330

VL - 99

SP - 1290

EP - 1292

JO - Circulation Research

JF - Circulation Research

IS - 12

ER -

Phospholemman and the cardiac sodium pump: Protein kinase C, take a bow

Abstract

Keywords

Access to Document

Fingerprint

Cite this