Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

Christophe Verbruggen, Sofie De Craecker, Padinchare Rajan, Xian Yun Jiao, Marianne Borloo, Keith Smith, Alan H. Fairlamb, Achiel Haemers (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    42 Citations (Scopus)

    Abstract

    A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine synthetase, an essential enzyme in the biosynthesis of trypanothione in trypanosomatids. The compounds showed moderate activity.

    Original languageEnglish
    Pages (from-to)253-258
    Number of pages6
    JournalBioorganic and Medicinal Chemistry Letters
    Volume6
    Issue number3
    DOIs
    Publication statusPublished - 6 Feb 1996

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