TY - JOUR
T1 - Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase
AU - Verbruggen, Christophe
AU - De Craecker, Sofie
AU - Rajan, Padinchare
AU - Jiao, Xian Yun
AU - Borloo, Marianne
AU - Smith, Keith
AU - Fairlamb, Alan H.
AU - Haemers, Achiel
N1 - Funding Information:
AcknowledgementsT. his work was supportedb y grantsf rom the UNDP/Worldbank/WH0S pecial Programmfeo r Researcha ndT rainingi n TropicalD isease(sT DR), the Belgian' qqationaaF!o ndsvoor WetensehappelijOkn derzoek", the "(3econeerteerdOc nderzoeksacti9e2 ./94-09"o f the Flemish Communityt, heW ellcomeT rustand the BritishC ouncil.
PY - 1996/2/6
Y1 - 1996/2/6
N2 - A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine synthetase, an essential enzyme in the biosynthesis of trypanothione in trypanosomatids. The compounds showed moderate activity.
AB - A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine synthetase, an essential enzyme in the biosynthesis of trypanothione in trypanosomatids. The compounds showed moderate activity.
UR - http://www.scopus.com/inward/record.url?scp=0030063434&partnerID=8YFLogxK
U2 - 10.1016/0960-894X(96)00001-7
DO - 10.1016/0960-894X(96)00001-7
M3 - Article
AN - SCOPUS:0030063434
SN - 0960-894X
VL - 6
SP - 253
EP - 258
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 3
ER -