Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

TY - JOUR

T1 - Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

AU - Verbruggen, Christophe

AU - De Craecker, Sofie

AU - Rajan, Padinchare

AU - Jiao, Xian Yun

AU - Borloo, Marianne

AU - Smith, Keith

AU - Fairlamb, Alan H.

AU - Haemers, Achiel

N1 - Funding Information: AcknowledgementsT. his work was supportedb y grantsf rom the UNDP/Worldbank/WH0S pecial Programmfeo r Researcha ndT rainingi n TropicalD isease(sT DR), the Belgian' qqationaaF!o ndsvoor WetensehappelijOkn derzoek", the "(3econeerteerdOc nderzoeksacti9e2 ./94-09"o f the Flemish Communityt, heW ellcomeT rustand the BritishC ouncil.

PY - 1996/2/6

Y1 - 1996/2/6

N2 - A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine synthetase, an essential enzyme in the biosynthesis of trypanothione in trypanosomatids. The compounds showed moderate activity.

AB - A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine synthetase, an essential enzyme in the biosynthesis of trypanothione in trypanosomatids. The compounds showed moderate activity.

UR - https://www.scopus.com/pages/publications/0030063434

U2 - 10.1016/0960-894X(96)00001-7

DO - 10.1016/0960-894X(96)00001-7

M3 - Article

AN - SCOPUS:0030063434

SN - 0960-894X

VL - 6

SP - 253

EP - 258

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -