Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells

D. W. Meek, W. Eckhart

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    We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.
    Original languageEnglish
    Pages (from-to)461-465
    Number of pages5
    JournalMolecular and Cellular Biology
    Issue number1
    Publication statusPublished - Jan 1988


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