Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells

D. W. Meek, W. Eckhart

    Research output: Contribution to journalArticle

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    Abstract

    We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.
    Original languageEnglish
    Pages (from-to)461-465
    Number of pages5
    JournalMolecular and Cellular Biology
    Volume8
    Issue number1
    DOIs
    Publication statusPublished - Jan 1988

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    NIH 3T3 Cells
    Simian virus 40
    Serine
    Phosphopeptides
    Phosphorylation

    Cite this

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    abstract = "We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.",
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    Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells. / Meek, D. W.; Eckhart, W.

    In: Molecular and Cellular Biology, Vol. 8, No. 1, 01.1988, p. 461-465.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells

    AU - Meek, D. W.

    AU - Eckhart, W.

    PY - 1988/1

    Y1 - 1988/1

    N2 - We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.

    AB - We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.

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    DO - 10.1128/MCB.8.1.461

    M3 - Article

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    EP - 465

    JO - Molecular and Cellular Biology

    JF - Molecular and Cellular Biology

    SN - 0270-7306

    IS - 1

    ER -