Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells

D. W. Meek; W. Eckhart

doi:10.1128/MCB.8.1.461

Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells

D. W. Meek
, W. Eckhart

Research output: Contribution to journal › Article › peer-review

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Abstract

We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.

Original language	English
Pages (from-to)	461-465
Number of pages	5
Journal	Molecular and Cellular Biology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1128/MCB.8.1.461
Publication status	Published - Jan 1988

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title = "Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells",

abstract = "We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.",

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year = "1988",

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AU - Meek, D. W.

AU - Eckhart, W.

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N2 - We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.

AB - We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.

U2 - 10.1128/MCB.8.1.461

DO - 10.1128/MCB.8.1.461

M3 - Article

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SN - 0270-7306

VL - 8

SP - 461

EP - 465

JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

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ER -

Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells

Abstract

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