Photodynamic diagnostic ureterorenoscopy with orally administered 5-aminolaevulinic acid as photosensitiser: how I do it

Slawomir G. Kata, Ghulam Nabi, Sam Eljamel, Piotr Chlosta, Harry Moseley, Omar M. Aboumarzouk (Lead / Corresponding author)

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    Objective: To explain our use of photodynamic diagnostic ureterorenoscopy, we provide a detailed description of the choice of photosensitiser, equipment needed, a safety profile, and pointers on our technique. Technique: Patients are given oral 5-aminolaevulinic acid (5-ALA) as a photosensitiser 3-4 h pre-operatively, and by using a Xenon blue light source, an eyepiece which blocks light below 450 nm which is fitted onto the ureterorenoscope, we are able to conduct a thorough photodiagnosis of the upper urinary tract. Conclusion: Our technique of photodynamic diagnostic ureterorenoscopy has shown that the sensitivity, specificity and detection rates of upper urinary tract lesions can be significantly increased with the use of oral 5-ALA. Therefore, we provide a detailed explanation of the use of oral 5-ALA photosensitiser, indications and contraindications of the technique in addition to equipment used and potential complications of the procedures. © 2014 S. Karger AG, Basel.
    Original languageEnglish
    Pages (from-to)384-388
    Number of pages5
    JournalUrologia Internationalis
    Issue number4
    Early online date24 Jul 2014
    Publication statusPublished - Dec 2014


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