Abstract
Locating DNA sequences to specific chromosomal segments is essential for associating genes with phenotypes. It is routinely achieved by segregation analysis using meiotic mapping populations that have also been used to collect phenotypic information. However, meiotic mapping is struggling to cope with the shear volume of sequences emerging from high-throughput (HTP) gene-discovery programs. We describe two approaches, Radiation Hybrid and 'HAPPY' mapping, which, in conjunction with meiotic mapping, represent valuable HTP tools in the quest to link genes to phenotypes.
| Original language | English |
|---|---|
| Pages (from-to) | 521-523 |
| Number of pages | 3 |
| Journal | Trends in Plant Science |
| Volume | 7 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1 Dec 2002 |
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Physical education - New technologies for mapping plant genomes. / Waugh, Robert (Lead / Corresponding author); Dear, Paul H.; Powell, Wayne; Machray, Gordon C.
In: Trends in Plant Science, Vol. 7, No. 12, 01.12.2002, p. 521-523.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Physical education - New technologies for mapping plant genomes
AU - Waugh, Robert
AU - Dear, Paul H.
AU - Powell, Wayne
AU - Machray, Gordon C.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Locating DNA sequences to specific chromosomal segments is essential for associating genes with phenotypes. It is routinely achieved by segregation analysis using meiotic mapping populations that have also been used to collect phenotypic information. However, meiotic mapping is struggling to cope with the shear volume of sequences emerging from high-throughput (HTP) gene-discovery programs. We describe two approaches, Radiation Hybrid and 'HAPPY' mapping, which, in conjunction with meiotic mapping, represent valuable HTP tools in the quest to link genes to phenotypes.
AB - Locating DNA sequences to specific chromosomal segments is essential for associating genes with phenotypes. It is routinely achieved by segregation analysis using meiotic mapping populations that have also been used to collect phenotypic information. However, meiotic mapping is struggling to cope with the shear volume of sequences emerging from high-throughput (HTP) gene-discovery programs. We describe two approaches, Radiation Hybrid and 'HAPPY' mapping, which, in conjunction with meiotic mapping, represent valuable HTP tools in the quest to link genes to phenotypes.
UR - http://www.scopus.com/inward/record.url?scp=0036886630&partnerID=8YFLogxK
U2 - 10.1016/S1360-1385(02)02373-7
DO - 10.1016/S1360-1385(02)02373-7
M3 - Short survey
C2 - 12475484
AN - SCOPUS:0036886630
VL - 7
SP - 521
EP - 523
JO - Trends in Plant Science
JF - Trends in Plant Science
SN - 1360-1385
IS - 12
ER -