Physical stability, biocompatibility and potential use of hybrid iron oxide-gold nanoparticles as drug carriers

Christopher M. Barnett, Mariana Gueorguieva, Martin R. Lees, David J. McGarvey, Clare Hoskins

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    12 Citations (Scopus)

    Abstract

    Hybrid nanoparticles (HNPs) such as iron oxide-gold nanoparticles are currently being exploited for their potential application in image-guided therapies. However, little investigation has been carried out into their physical or chemical stability and potential cytotoxicity in biological systems. Here, we determine the HNPs physical stability over 6 months and chemical stability in physiological conditions, and estimate the biological activity of uncoated and poly(ethylene glycol) coated nanoparticles on human pancreatic adenocarcinoma (BxPC-3) and differentiated human monocyte cells (U937). The potential of these HNPs to act as drug carrier vehicles was determined using the model drug 6-Thioguanine (6-TG). The data showed that the HNPs maintained their structural integrity both physically and chemically throughout the duration of the studies. In addition, negligible cytotoxicity or free radical production was observed in the cell lines tested. The 6-TG was successfully conjugated; with a ratio of 3:1:10 Fe:Au:6-TG (wt:wt:wt). After incubation with BxPC-3 cells, enhanced cellular uptake was reported with the 6-TG-conjugated HNPs compared with free drug along with a 10-fold decrease in IC50. This exciting data highlights the potential of HNPs for use in image-guided drug delivery.

    Original languageEnglish
    Article numberUNSP 1706
    Number of pages14
    JournalJournal of Nanoparticle Research
    Volume15
    Issue number6
    DOIs
    Publication statusPublished - Jun 2013

    Keywords

    • Drug delivery
    • Biocompatibility
    • Hybrid nanoparticle
    • MAGNETIC NANOPARTICLES
    • PHYSICOCHEMICAL PROPERTIES
    • Gold nano-shell
    • CELL LINE
    • Magnetic nanoparticle
    • LEUKEMIA
    • Stability
    • DELIVERY
    • PARTICLES
    • DENSITY
    • SIZE

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