Physiological and pathophysiological aspects of primary cilia—a literature review with view on functional and structural relationships in cartilage

Friedrich Barsch, Tanja Niedermair, Andreas Mamilos, Volker H. Schmitt, David Grevenstein, Maximilian Babel, Thomas Burgoyne, Amelia Shoemark, Christoph Brochhausen (Lead / Corresponding author)

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Abstract

Cilia are cellular organelles that project from the cell. They occur in nearly all non-hematopoietic tissues and have different functions in different tissues. In mesenchymal tissues primary cilia play a crucial role in the adequate morphogenesis during embryological development. In mature articular cartilage, primary cilia fulfil chemo-and mechanosensitive functions to adapt the cellular mechanisms on extracellular changes and thus, maintain tissue homeostasis and morphometry. Ciliary abnormalities in osteoarthritic cartilage could represent pathophysiological relationships between ciliary dysfunction and tissue deformation. Nevertheless, the molecular and pathophysiological relationships of ‘Primary Cilia’ (PC) in the context of osteoarthritis is not yet fully understood. The present review focuses on the current knowledge about PC and provide a short but not exhaustive overview of their role in cartilage.

Original languageEnglish
Article number4959
Number of pages19
JournalInternational Journal of Molecular Sciences
Volume21
Issue number14
DOIs
Publication statusPublished - 14 Jul 2020

Keywords

  • Cartilage
  • Mechanotransduction
  • Osteoarthritis
  • Primary cilia

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