Physiological functions of mitophagy

TY - JOUR

T1 - Physiological functions of mitophagy

AU - Stanojlovic, Milos

AU - Bishnu, Aniketh

AU - Singh, Francois

AU - Ganley, Ian G.

N1 - Funding Information: This work was funded by a grant from the Medical Research Council, UK (IGG; MC_UU_00018/2 ). Publisher Copyright: © 2022 The Authors

PY - 2022/12

Y1 - 2022/12

N2 - Mitochondria are vitally important organelles within our cells. In addition to being the key energy provider, they perform numerous other essential roles ranging from calcium homeostasis to iron metabolism. Therefore, these mitochondrial functions are dependent on the quality and number of mitochondria, which needs to be dynamic in response to a cell's changing needs. Mitochondrial numbers themselves are controlled by mitochondrial biogenesis and turnover. Multiple pathways exist that result in the turnover of mitochondria, but the focus of this review will be on mitophagy (the autophagy of mitochondria). Here, we will touch on the basic mechanisms of mitophagy and how this has been translated from cell-based studies to complex mammalian systems. We will then examine the tasks that mitophagy serves in vivo. While mitochondrial quality control is a critical function of mitophagy, we will also discuss the recent roles that mitophagy plays in metabolic remodeling.

AB - Mitochondria are vitally important organelles within our cells. In addition to being the key energy provider, they perform numerous other essential roles ranging from calcium homeostasis to iron metabolism. Therefore, these mitochondrial functions are dependent on the quality and number of mitochondria, which needs to be dynamic in response to a cell's changing needs. Mitochondrial numbers themselves are controlled by mitochondrial biogenesis and turnover. Multiple pathways exist that result in the turnover of mitochondria, but the focus of this review will be on mitophagy (the autophagy of mitochondria). Here, we will touch on the basic mechanisms of mitophagy and how this has been translated from cell-based studies to complex mammalian systems. We will then examine the tasks that mitophagy serves in vivo. While mitochondrial quality control is a critical function of mitophagy, we will also discuss the recent roles that mitophagy plays in metabolic remodeling.

UR - https://www.scopus.com/pages/publications/85141921253

U2 - 10.1016/j.cophys.2022.100612

DO - 10.1016/j.cophys.2022.100612

M3 - Review article

AN - SCOPUS:85141921253

SN - 2468-8673

VL - 30

JO - Current Opinion in Physiology

JF - Current Opinion in Physiology

M1 - 100612

ER -