Physiology of aldosterone and pharmacology of aldosterone blockers

Allan D. Struthers; Thomas Unger

doi:10.1093/eurheartj/sur009

Physiology of aldosterone and pharmacology of aldosterone blockers

Allan D. Struthers, Thomas Unger

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

New adverse effects of aldosterone are now apparent: endothelial dysfunction, myocardial fibrosis and LV remodelling. Aldosterone blockade is able to reverse these adverse effects and so reduce mortality in heart failure. Pharmacological differences between spironolactone and eplerenone are discussed.

Original language	English
Pages (from-to)	B27-B30
Number of pages	4
Journal	European Heart Journal Supplements
Volume	13
Issue number	B
DOIs	https://doi.org/10.1093/eurheartj/sur009
Publication status	Published - Jul 2011

Keywords

Aldosterone blocker
Hypertension
Spironolactone
Eplerenone
Pharmacology
Heart failure
CHRONIC HEART-FAILURE
RATE-VARIABILITY
SPIRONOLACTONE
EPLERENONE
DYSFUNCTION
MORBIDITY
MORTALITY
TURNOVER
BLOCKADE

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10.1093/eurheartj/sur009

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title = "Physiology of aldosterone and pharmacology of aldosterone blockers",

abstract = "New adverse effects of aldosterone are now apparent: endothelial dysfunction, myocardial fibrosis and LV remodelling. Aldosterone blockade is able to reverse these adverse effects and so reduce mortality in heart failure. Pharmacological differences between spironolactone and eplerenone are discussed.",

keywords = "Aldosterone blocker, Hypertension, Spironolactone, Eplerenone, Pharmacology, Heart failure, CHRONIC HEART-FAILURE, RATE-VARIABILITY, SPIRONOLACTONE, EPLERENONE, DYSFUNCTION, MORBIDITY, MORTALITY, TURNOVER, BLOCKADE",

author = "Struthers, {Allan D.} and Thomas Unger",

year = "2011",

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doi = "10.1093/eurheartj/sur009",

language = "English",

volume = "13",

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AU - Struthers, Allan D.

AU - Unger, Thomas

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AB - New adverse effects of aldosterone are now apparent: endothelial dysfunction, myocardial fibrosis and LV remodelling. Aldosterone blockade is able to reverse these adverse effects and so reduce mortality in heart failure. Pharmacological differences between spironolactone and eplerenone are discussed.

KW - Aldosterone blocker

KW - Hypertension

KW - Spironolactone

KW - Eplerenone

KW - Pharmacology

KW - Heart failure

KW - CHRONIC HEART-FAILURE

KW - RATE-VARIABILITY

KW - SPIRONOLACTONE

KW - EPLERENONE

KW - DYSFUNCTION

KW - MORBIDITY

KW - MORTALITY

KW - TURNOVER

KW - BLOCKADE

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DO - 10.1093/eurheartj/sur009

M3 - Article

SN - 1520-765X

VL - 13

SP - B27-B30

JO - European Heart Journal Supplements

JF - European Heart Journal Supplements

IS - B

ER -

Physiology of aldosterone and pharmacology of aldosterone blockers

Abstract

Keywords

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