Physiology of aldosterone and pharmacology of aldosterone blockers

Allan D. Struthers, Thomas Unger

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    New adverse effects of aldosterone are now apparent: endothelial dysfunction, myocardial fibrosis and LV remodelling. Aldosterone blockade is able to reverse these adverse effects and so reduce mortality in heart failure. Pharmacological differences between spironolactone and eplerenone are discussed.

    Original languageEnglish
    Pages (from-to)B27-B30
    Number of pages4
    JournalEuropean Heart Journal Supplements
    Volume13
    Issue numberB
    DOIs
    Publication statusPublished - Jul 2011

    Keywords

    • Aldosterone blocker
    • Hypertension
    • Spironolactone
    • Eplerenone
    • Pharmacology
    • Heart failure
    • CHRONIC HEART-FAILURE
    • RATE-VARIABILITY
    • SPIRONOLACTONE
    • EPLERENONE
    • DYSFUNCTION
    • MORBIDITY
    • MORTALITY
    • TURNOVER
    • BLOCKADE

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