PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models

Emmanuelle Astoul, Catherine Edmunds, Doreen A. Cantrell, Stephen G. Ward

    Research output: Contribution to journalReview article

    97 Citations (Scopus)

    Abstract

    Phosphoinositide 3-kinases (PI 3-Ks) phosphorylate the D3-hydroxyl position of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2] resulting in the generation of the 3′-phosphoinositide lipid PtdIns(3,4,5)P3. PI 3-Ks are activated by a diverse set of receptors that play a role in determining T-cell function. It now seems that leukemic T cells, which are widely used as models for T-cell biology, show constitutive activation of PI 3-K-mediated signal-transduction pathways. Hence, studies of the role of PI 3-K in T-cell biology using leukemic cell lines might have misinterpreted the importance of this pathway for T-cell signal transduction.

    Original languageEnglish
    Pages (from-to)490-496
    Number of pages7
    JournalTrends in Immunology
    Volume22
    Issue number9
    DOIs
    Publication statusPublished - 1 Sep 2001

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