TY - JOUR
T1 - PI 3-K and T-cell activation
T2 - limitations of T-leukemic cell lines as signaling models
AU - Astoul, Emmanuelle
AU - Edmunds, Catherine
AU - Cantrell, Doreen A.
AU - Ward, Stephen G.
PY - 2001/9/1
Y1 - 2001/9/1
N2 - Phosphoinositide 3-kinases (PI 3-Ks) phosphorylate the D3-hydroxyl position of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2] resulting in the generation of the 3′-phosphoinositide lipid PtdIns(3,4,5)P3. PI 3-Ks are activated by a diverse set of receptors that play a role in determining T-cell function. It now seems that leukemic T cells, which are widely used as models for T-cell biology, show constitutive activation of PI 3-K-mediated signal-transduction pathways. Hence, studies of the role of PI 3-K in T-cell biology using leukemic cell lines might have misinterpreted the importance of this pathway for T-cell signal transduction.
AB - Phosphoinositide 3-kinases (PI 3-Ks) phosphorylate the D3-hydroxyl position of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2] resulting in the generation of the 3′-phosphoinositide lipid PtdIns(3,4,5)P3. PI 3-Ks are activated by a diverse set of receptors that play a role in determining T-cell function. It now seems that leukemic T cells, which are widely used as models for T-cell biology, show constitutive activation of PI 3-K-mediated signal-transduction pathways. Hence, studies of the role of PI 3-K in T-cell biology using leukemic cell lines might have misinterpreted the importance of this pathway for T-cell signal transduction.
UR - http://www.scopus.com/inward/record.url?scp=0035451761&partnerID=8YFLogxK
U2 - 10.1016/S1471-4906(01)01973-1
DO - 10.1016/S1471-4906(01)01973-1
M3 - Review article
C2 - 11525939
AN - SCOPUS:0035451761
SN - 1471-4906
VL - 22
SP - 490
EP - 496
JO - Trends in Immunology
JF - Trends in Immunology
IS - 9
ER -