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Abstract
Investigations over half a century have indicated that mechanical forces induce neurite growth, with neurites elongating at a rate of 0.1–0.3 μm h−1 pN−1 when mechanical force exceeds a threshold, with this being identified as 400–1000 pN for neurites of PC12 cells. In this article, we demonstrate that neurite elongation of PC12 cells proceeds at the same previously identified rate on application of mechanical tension of ∼1 pN, which is significantly lower than the force generated in vivo by axons and growth cones. This observation raises the possibility that mechanical tension may act as an endogenous signal used by neurons for promoting neurite elongation.
Original language | English |
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Pages (from-to) | 2026-2033 |
Number of pages | 8 |
Journal | Biophysical Journal |
Volume | 115 |
Issue number | 10 |
Early online date | 16 Oct 2018 |
DOIs | |
Publication status | Published - 20 Nov 2018 |
ASJC Scopus subject areas
- Biophysics
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Dive into the research topics of 'Piconewton Mechanical Forces Promote Neurite Growth'. Together they form a unique fingerprint.Projects
- 1 Finished
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Magnetically Enhanced Controlled Axonal Regeneration (MECAR) (Marie Curie Intra European Fellowship)
Cuschieri, A. (Investigator) & Raffa, V. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
7/07/14 → 6/07/16
Project: Research