PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

Agne Kazlauskaite, Miratul M. K. Muqit (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    53 Citations (Scopus)

    Abstract

    The discovery of mutations in genes encoding protein kinase PTEN-induced kinase 1 (PINK1) and E3 ubiquitin ligase Parkin in familial Parkinson's disease and their association with mitochondria provides compelling evidence that mitochondrial dysfunction is a major contributor to neurodegeneration in Parkinson's disease. In recent years, tremendous progress has been made in the understanding of how PINK1 and Parkin enzymes are regulated and how they influence downstream mitochondrial signalling processes. We provide a critical overview of the key advances in the field and also discuss the outstanding questions, including novel ways in which this knowledge could be exploited to develop therapies against Parkinson's disease.

    Original languageEnglish
    Pages (from-to)215-223
    Number of pages9
    JournalFEBS Journal
    Volume282
    Issue number2
    DOIs
    Publication statusPublished - Jan 2015

    Keywords

    • kinase
    • mitochondria
    • parkin
    • Parkinson's disease
    • PINK1
    • ubiquitin

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