Projects per year
Abstract
The discovery of mutations in genes encoding protein kinase PTEN-induced kinase 1 (PINK1) and E3 ubiquitin ligase Parkin in familial Parkinson's disease and their association with mitochondria provides compelling evidence that mitochondrial dysfunction is a major contributor to neurodegeneration in Parkinson's disease. In recent years, tremendous progress has been made in the understanding of how PINK1 and Parkin enzymes are regulated and how they influence downstream mitochondrial signalling processes. We provide a critical overview of the key advances in the field and also discuss the outstanding questions, including novel ways in which this knowledge could be exploited to develop therapies against Parkinson's disease.
Original language | English |
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Pages (from-to) | 215-223 |
Number of pages | 9 |
Journal | FEBS Journal |
Volume | 282 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jan 2015 |
Keywords
- kinase
- mitochondria
- parkin
- Parkinson's disease
- PINK1
- ubiquitin
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
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Dive into the research topics of 'PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease'. Together they form a unique fingerprint.Projects
- 2 Finished
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Investigation of the Regulation of Rab GTPases by PINK1 (PhD Studentship)
7/09/15 → 6/09/18
Project: Research