PIPs: human protein-protein interaction prediction database

Mark D. McDowall, Michelle S. Scott, Geoffrey J. Barton

    Research output: Contribution to journalArticlepeer-review

    152 Citations (Scopus)

    Abstract

    The PIPs database (http://www.compbio.dundee.ac.uk/www-pips) is a resource for studying protein protein interactions in human. It contains predictions of > 37000 high probability interactions of which > 34000 are not reported in the interaction databases HPRD, BIND, DIP or OPHID. The interactions in PIPs were calculated by a Bayesian method that combines information from expression, orthology, domain co-occurrence, post-translational modifications and sub-cellular location. The predictions also take account of the topology of the predicted interaction network. The web interface to PIPs ranks predictions according to their likelihood of interaction broken down by the contribution from each information source and with easy access to the evidence that supports each prediction. Where data exists in OPHID, HPRD, DIP or BIND for a protein pair this is also reported in the output tables returned by a search. A network browser is included to allow convenient browsing of the interaction network for any protein in the database. The PIPs database provides a new resource on protein-protein interactions in human that is straightforward to browse, or can be exploited completely, for interaction network modelling.

    Original languageEnglish
    Pages (from-to)D651-D656
    Number of pages6
    JournalNucleic Acids Research
    Volume37
    Issue numberSuppl 1
    DOIs
    Publication statusPublished - Jan 2009

    Keywords

    • Databases, Protein
    • Humans
    • Internet
    • Protein Interaction Mapping
    • Proteins
    • User-Computer Interface

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