Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality: new data and meta-analyses

Gordon D. O. Lowe; Katie Harris; Wolfgang Koenig; Yoav Ben-Shlomo; Barbara Thorand; Annette Peters; Christa Meisinger; Armin Imhof; Hugh Tunstall-Pedoe; Sanne A. E. Peters; Mark Woodward

doi:10.1136/jcp-2022-208223

Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality: new data and meta-analyses

Gordon D. O. Lowe
, Katie Harris (Lead / Corresponding author)
, Wolfgang Koenig
, Yoav Ben-Shlomo
, Barbara Thorand
, Annette Peters
, Christa Meisinger
, Armin Imhof
, Hugh Tunstall-Pedoe
, Sanne A. E. Peters
, Mark Woodward

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Aims: Associations of plasma viscosity and plasma Ig levels (a determinant of viscosity) with incident coronary heart disease (CHD) events; and with CHD, cardiovascular disease (CVD: CHD and stroke) and all-cause mortalities.

Methods: Meta-analysis of plasma viscosity levels from the MONitoring of trends and determinants of CArdiovascular (MONICA)/Cooperative Health Research in the Region of Augsburg, MONICA Glasgow and Speedwell Studies; and five other published studies. Meta-analysis of IgA, IgG and IgM levels from the Augsburg, Glasgow and Speedwell studies; and one other published study.

Results: Over median follow-up periods of 14-26 years, there were 2270 CHD events, and 4220 all cause deaths in 28 605 participants with baseline plasma viscosity measurements. After adjustment for major risk factors, (HRs; 95% CIs) for a 1 SD increase in viscosity were 1.14 (1.09 to 1.20) for CHD events; and 1.21 (1.17 to 1.25) for all-cause mortality. 821 CHD events and 2085 all-cause deaths occurred in 8218 participants with baseline Ig levels. For CHD events, adjusted HRs for 1 SD increases in IgA, IgG and IgM were, respectively, 0.97 (0.89 to 1.05); 0.95(0.76 to 1.17) and 0.90 (0.79 to 1.03). Corresponding adjusted HRs for all-cause mortality were 1.08 (95% CI 1.02 to 1.13), 1.03 (95% CI 0.94 to 1.14) and 1.01 (95% CI 0.96 to 1.06).

Conclusions: After risk factor adjustment, plasma viscosity was significantly associated with risks of CHD events; and with CHD, CVD and all-cause mortalities. We found no significant association of IgA, IgG or IgM levels with incident CHD events or mortality, except for a borderline association of IgA with all-cause mortality.

Original language	English
Pages (from-to)	394-401
Number of pages	8
Journal	Journal of Clinical Pathology
Volume	77
Issue number	6
Early online date	24 Feb 2023
DOIs	https://doi.org/10.1136/jcp-2022-208223
Publication status	Published - Jun 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Blood Viscosity
Cardiovascular Diseases
Immunoglobulins

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1136/jcp-2022-208223

Cite this

@article{9f9ffb3277114e158f2c0f402cb61ed5,

title = "Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality: new data and meta-analyses",

abstract = "Aims: Associations of plasma viscosity and plasma Ig levels (a determinant of viscosity) with incident coronary heart disease (CHD) events; and with CHD, cardiovascular disease (CVD: CHD and stroke) and all-cause mortalities.Methods: Meta-analysis of plasma viscosity levels from the MONitoring of trends and determinants of CArdiovascular (MONICA)/Cooperative Health Research in the Region of Augsburg, MONICA Glasgow and Speedwell Studies; and five other published studies. Meta-analysis of IgA, IgG and IgM levels from the Augsburg, Glasgow and Speedwell studies; and one other published study.Results: Over median follow-up periods of 14-26 years, there were 2270 CHD events, and 4220 all cause deaths in 28 605 participants with baseline plasma viscosity measurements. After adjustment for major risk factors, (HRs; 95\% CIs) for a 1 SD increase in viscosity were 1.14 (1.09 to 1.20) for CHD events; and 1.21 (1.17 to 1.25) for all-cause mortality. 821 CHD events and 2085 all-cause deaths occurred in 8218 participants with baseline Ig levels. For CHD events, adjusted HRs for 1 SD increases in IgA, IgG and IgM were, respectively, 0.97 (0.89 to 1.05); 0.95(0.76 to 1.17) and 0.90 (0.79 to 1.03). Corresponding adjusted HRs for all-cause mortality were 1.08 (95\% CI 1.02 to 1.13), 1.03 (95\% CI 0.94 to 1.14) and 1.01 (95\% CI 0.96 to 1.06).Conclusions: After risk factor adjustment, plasma viscosity was significantly associated with risks of CHD events; and with CHD, CVD and all-cause mortalities. We found no significant association of IgA, IgG or IgM levels with incident CHD events or mortality, except for a borderline association of IgA with all-cause mortality.",

keywords = "Blood Viscosity, Cardiovascular Diseases, Immunoglobulins",

author = "Lowe, \{Gordon D. O.\} and Katie Harris and Wolfgang Koenig and Yoav Ben-Shlomo and Barbara Thorand and Annette Peters and Christa Meisinger and Armin Imhof and Hugh Tunstall-Pedoe and Peters, \{Sanne A. E.\} and Mark Woodward",

note = "Copyright: {\textcopyright} Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2024",

month = jun,

doi = "10.1136/jcp-2022-208223",

language = "English",

volume = "77",

pages = "394--401",

journal = "Journal of Clinical Pathology",

issn = "0021-9746",

publisher = "BMJ Publishing Group",

number = "6",

}

TY - JOUR

T1 - Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality

T2 - new data and meta-analyses

AU - Lowe, Gordon D. O.

AU - Harris, Katie

AU - Koenig, Wolfgang

AU - Ben-Shlomo, Yoav

AU - Thorand, Barbara

AU - Peters, Annette

AU - Meisinger, Christa

AU - Imhof, Armin

AU - Tunstall-Pedoe, Hugh

AU - Peters, Sanne A. E.

AU - Woodward, Mark

PY - 2024/6

Y1 - 2024/6

N2 - Aims: Associations of plasma viscosity and plasma Ig levels (a determinant of viscosity) with incident coronary heart disease (CHD) events; and with CHD, cardiovascular disease (CVD: CHD and stroke) and all-cause mortalities.Methods: Meta-analysis of plasma viscosity levels from the MONitoring of trends and determinants of CArdiovascular (MONICA)/Cooperative Health Research in the Region of Augsburg, MONICA Glasgow and Speedwell Studies; and five other published studies. Meta-analysis of IgA, IgG and IgM levels from the Augsburg, Glasgow and Speedwell studies; and one other published study.Results: Over median follow-up periods of 14-26 years, there were 2270 CHD events, and 4220 all cause deaths in 28 605 participants with baseline plasma viscosity measurements. After adjustment for major risk factors, (HRs; 95% CIs) for a 1 SD increase in viscosity were 1.14 (1.09 to 1.20) for CHD events; and 1.21 (1.17 to 1.25) for all-cause mortality. 821 CHD events and 2085 all-cause deaths occurred in 8218 participants with baseline Ig levels. For CHD events, adjusted HRs for 1 SD increases in IgA, IgG and IgM were, respectively, 0.97 (0.89 to 1.05); 0.95(0.76 to 1.17) and 0.90 (0.79 to 1.03). Corresponding adjusted HRs for all-cause mortality were 1.08 (95% CI 1.02 to 1.13), 1.03 (95% CI 0.94 to 1.14) and 1.01 (95% CI 0.96 to 1.06).Conclusions: After risk factor adjustment, plasma viscosity was significantly associated with risks of CHD events; and with CHD, CVD and all-cause mortalities. We found no significant association of IgA, IgG or IgM levels with incident CHD events or mortality, except for a borderline association of IgA with all-cause mortality.

AB - Aims: Associations of plasma viscosity and plasma Ig levels (a determinant of viscosity) with incident coronary heart disease (CHD) events; and with CHD, cardiovascular disease (CVD: CHD and stroke) and all-cause mortalities.Methods: Meta-analysis of plasma viscosity levels from the MONitoring of trends and determinants of CArdiovascular (MONICA)/Cooperative Health Research in the Region of Augsburg, MONICA Glasgow and Speedwell Studies; and five other published studies. Meta-analysis of IgA, IgG and IgM levels from the Augsburg, Glasgow and Speedwell studies; and one other published study.Results: Over median follow-up periods of 14-26 years, there were 2270 CHD events, and 4220 all cause deaths in 28 605 participants with baseline plasma viscosity measurements. After adjustment for major risk factors, (HRs; 95% CIs) for a 1 SD increase in viscosity were 1.14 (1.09 to 1.20) for CHD events; and 1.21 (1.17 to 1.25) for all-cause mortality. 821 CHD events and 2085 all-cause deaths occurred in 8218 participants with baseline Ig levels. For CHD events, adjusted HRs for 1 SD increases in IgA, IgG and IgM were, respectively, 0.97 (0.89 to 1.05); 0.95(0.76 to 1.17) and 0.90 (0.79 to 1.03). Corresponding adjusted HRs for all-cause mortality were 1.08 (95% CI 1.02 to 1.13), 1.03 (95% CI 0.94 to 1.14) and 1.01 (95% CI 0.96 to 1.06).Conclusions: After risk factor adjustment, plasma viscosity was significantly associated with risks of CHD events; and with CHD, CVD and all-cause mortalities. We found no significant association of IgA, IgG or IgM levels with incident CHD events or mortality, except for a borderline association of IgA with all-cause mortality.

KW - Blood Viscosity

KW - Cardiovascular Diseases

KW - Immunoglobulins

U2 - 10.1136/jcp-2022-208223

DO - 10.1136/jcp-2022-208223

M3 - Article

C2 - 36828622

SN - 0021-9746

VL - 77

SP - 394

EP - 401

JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

IS - 6

ER -

Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality: new data and meta-analyses

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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