"Plasmo2D": An Ancillary Proteomic Tool to Aid Identification of Proteins from Plasmodium falciparum

Amit Khachane; Ranjit Kumar; Sanyam Jain; Samta Jain; Gowrishankar Banumathy; Varsha Singh; Saurabh Nagpal; Utpal Tatu

doi:10.1021/pr050289p

"Plasmo2D": An Ancillary Proteomic Tool to Aid Identification of Proteins from Plasmodium falciparum

Amit Khachane
, Ranjit Kumar
, Sanyam Jain
, Samta Jain
, Gowrishankar Banumathy
, Varsha Singh
, Saurabh Nagpal
, Utpal Tatu (Lead / Corresponding author)

Molecular Microbiology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Bioinformatics tools to aid gene and protein sequence analysis have become an integral part of biology in the post-genomic era. Release of the Plasmodium falciparum genome sequence has allowed biologists to define the gene and the predicted protein content as well as their sequences in the parasite. Using p/ and molecular weight as characteristics unique to each protein, we have developed a bioinformatics tool to aid identification of proteins from Plasmodium falciparum. The tool makes use of a Virtual 2-DE generated by plotting all of the proteins from the Plasmodium database on a p/ versus molecular weight scale. Proteins are identified by comparing the position of migration of desired protein spots from an experimental 2-DE and that on a virtual 2-DE. The procedure has been automated in the form of user-friendly software called "Plasmo2D".

Original language	English
Pages (from-to)	2369-2374
Number of pages	6
Journal	Journal of Proteome Research
Volume	4
Issue number	6
Early online date	18 Oct 2005
DOIs	https://doi.org/10.1021/pr050289p
Publication status	Published - 1 Dec 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bioinformatics
Heat shock proteins
Malaria
Plasmo2D
Proteomics

ASJC Scopus subject areas

General Chemistry
Biochemistry

Access to Document

10.1021/pr050289p

Cite this

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abstract = "Bioinformatics tools to aid gene and protein sequence analysis have become an integral part of biology in the post-genomic era. Release of the Plasmodium falciparum genome sequence has allowed biologists to define the gene and the predicted protein content as well as their sequences in the parasite. Using p/ and molecular weight as characteristics unique to each protein, we have developed a bioinformatics tool to aid identification of proteins from Plasmodium falciparum. The tool makes use of a Virtual 2-DE generated by plotting all of the proteins from the Plasmodium database on a p/ versus molecular weight scale. Proteins are identified by comparing the position of migration of desired protein spots from an experimental 2-DE and that on a virtual 2-DE. The procedure has been automated in the form of user-friendly software called {"}Plasmo2D{"}.",

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author = "Amit Khachane and Ranjit Kumar and Sanyam Jain and Samta Jain and Gowrishankar Banumathy and Varsha Singh and Saurabh Nagpal and Utpal Tatu",

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AU - Khachane, Amit

AU - Kumar, Ranjit

AU - Jain, Sanyam

AU - Jain, Samta

AU - Banumathy, Gowrishankar

AU - Singh, Varsha

AU - Nagpal, Saurabh

AU - Tatu, Utpal

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AB - Bioinformatics tools to aid gene and protein sequence analysis have become an integral part of biology in the post-genomic era. Release of the Plasmodium falciparum genome sequence has allowed biologists to define the gene and the predicted protein content as well as their sequences in the parasite. Using p/ and molecular weight as characteristics unique to each protein, we have developed a bioinformatics tool to aid identification of proteins from Plasmodium falciparum. The tool makes use of a Virtual 2-DE generated by plotting all of the proteins from the Plasmodium database on a p/ versus molecular weight scale. Proteins are identified by comparing the position of migration of desired protein spots from an experimental 2-DE and that on a virtual 2-DE. The procedure has been automated in the form of user-friendly software called "Plasmo2D".

KW - Bioinformatics

KW - Heat shock proteins

KW - Malaria

KW - Plasmo2D

KW - Proteomics

UR - https://www.scopus.com/pages/publications/29144503217

U2 - 10.1021/pr050289p

DO - 10.1021/pr050289p

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AN - SCOPUS:29144503217

SN - 1535-3893

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"Plasmo2D": An Ancillary Proteomic Tool to Aid Identification of Proteins from Plasmodium falciparum

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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