Polar transport in the Drosophila oocyte requires Dynein and Kinesin I cooperation

Jens Januschke; Louis Gervais; Sajith Dass; Andrea H. Brand; Julia A Kaltschmidt; Hernan Lopez-Schier; Daniel St Johnston; Siegfried Roth; Antoine Guichet

doi:10.1016/S0960-9822(02)01302-7

Polar transport in the Drosophila oocyte requires Dynein and Kinesin I cooperation

Jens Januschke, Louis Gervais, Sajith Dass, Andrea H. Brand, Julia A Kaltschmidt, Hernan Lopez-Schier, Daniel St Johnston, Siegfried Roth, Antoine Guichet

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184 Citations (Scopus)

Abstract

The cytoskeleton and associated motors play an important role in the establishment of intracellular polarity. Microtubule-based transport is required in many cell types for the asymmetric localization of mRNAs and organelles. A striking example is the Drosophila oocyte, where microtubule-dependent processes govern the asymmetric positioning of the nucleus and the localization to distinct cortical domains of mRNAs that function as cytoplasmic determinants. A conserved machinery for mRNA localization and nuclear positioning involving cytoplasmic Dynein has been postulated; however, the precise role of plus- and minus end-directed microtubule-based transport in axis formation is not yet understood.

Original language	English
Pages (from-to)	1971-1981
Number of pages	11
Journal	Current Biology
Volume	12
Issue number	23
DOIs	https://doi.org/10.1016/S0960-9822(02)01302-7
Publication status	Published - 2002

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title = "Polar transport in the Drosophila oocyte requires Dynein and Kinesin I cooperation",

abstract = "The cytoskeleton and associated motors play an important role in the establishment of intracellular polarity. Microtubule-based transport is required in many cell types for the asymmetric localization of mRNAs and organelles. A striking example is the Drosophila oocyte, where microtubule-dependent processes govern the asymmetric positioning of the nucleus and the localization to distinct cortical domains of mRNAs that function as cytoplasmic determinants. A conserved machinery for mRNA localization and nuclear positioning involving cytoplasmic Dynein has been postulated; however, the precise role of plus- and minus end-directed microtubule-based transport in axis formation is not yet understood.",

author = "Jens Januschke and Louis Gervais and Sajith Dass and Brand, {Andrea H.} and Kaltschmidt, {Julia A} and Hernan Lopez-Schier and {St Johnston}, Daniel and Siegfried Roth and Antoine Guichet",

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T1 - Polar transport in the Drosophila oocyte requires Dynein and Kinesin I cooperation

AU - Januschke, Jens

AU - Gervais, Louis

AU - Dass, Sajith

AU - Brand, Andrea H.

AU - Kaltschmidt, Julia A

AU - Lopez-Schier, Hernan

AU - St Johnston, Daniel

AU - Roth, Siegfried

AU - Guichet, Antoine

PY - 2002

Y1 - 2002

N2 - The cytoskeleton and associated motors play an important role in the establishment of intracellular polarity. Microtubule-based transport is required in many cell types for the asymmetric localization of mRNAs and organelles. A striking example is the Drosophila oocyte, where microtubule-dependent processes govern the asymmetric positioning of the nucleus and the localization to distinct cortical domains of mRNAs that function as cytoplasmic determinants. A conserved machinery for mRNA localization and nuclear positioning involving cytoplasmic Dynein has been postulated; however, the precise role of plus- and minus end-directed microtubule-based transport in axis formation is not yet understood.

AB - The cytoskeleton and associated motors play an important role in the establishment of intracellular polarity. Microtubule-based transport is required in many cell types for the asymmetric localization of mRNAs and organelles. A striking example is the Drosophila oocyte, where microtubule-dependent processes govern the asymmetric positioning of the nucleus and the localization to distinct cortical domains of mRNAs that function as cytoplasmic determinants. A conserved machinery for mRNA localization and nuclear positioning involving cytoplasmic Dynein has been postulated; however, the precise role of plus- and minus end-directed microtubule-based transport in axis formation is not yet understood.

U2 - 10.1016/S0960-9822(02)01302-7

DO - 10.1016/S0960-9822(02)01302-7

M3 - Article

C2 - 12477385

SN - 0960-9822

VL - 12

SP - 1971

EP - 1981

JO - Current Biology

JF - Current Biology

IS - 23

ER -

Polar transport in the Drosophila oocyte requires Dynein and Kinesin I cooperation

Abstract

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