Polar transport in the Drosophila oocyte requires Dynein and Kinesin I cooperation

Jens Januschke, Louis Gervais, Sajith Dass, Andrea H. Brand, Julia A Kaltschmidt, Hernan Lopez-Schier, Daniel St Johnston, Siegfried Roth, Antoine Guichet

    Research output: Contribution to journalArticlepeer-review

    167 Citations (Scopus)

    Abstract

    The cytoskeleton and associated motors play an important role in the establishment of intracellular polarity. Microtubule-based transport is required in many cell types for the asymmetric localization of mRNAs and organelles. A striking example is the Drosophila oocyte, where microtubule-dependent processes govern the asymmetric positioning of the nucleus and the localization to distinct cortical domains of mRNAs that function as cytoplasmic determinants. A conserved machinery for mRNA localization and nuclear positioning involving cytoplasmic Dynein has been postulated; however, the precise role of plus- and minus end-directed microtubule-based transport in axis formation is not yet understood.
    Original languageEnglish
    Pages (from-to)1971-1981
    Number of pages11
    JournalCurrent Biology
    Volume12
    Issue number23
    DOIs
    Publication statusPublished - 2002

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