The growing trends of poly-substance use and associated health and public concerns have been reported in various studies with particular focus on young adults patronising popular recreational settings. Harm reduction interventions targeting this population have been reported for a number of settings, however only limited data is available on the current strategies employed. A systematic review of peer-reviewed journals was conducted to determine interventions published since 1998 which targeted 17-24 year olds within recreational settings: defined as clubs, pubs, discos, festivals or raves. The identified studies were examined for similarities in design, implementation and outcome measures. The findings and their limitations are discussed alongside implications for future research needed to fill a void in the current knowledge base. (C) 2010 Elsevier Ltd. All rights reserved.