Polybacterial human disease: the ills of social networking

Francesca L. Short, Sarah L. Murdoch, Robert P. Ryan (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    69 Citations (Scopus)

    Abstract

    Polybacterial diseases involve multiple organisms that act collectively to facilitate disease progression. Although this phenomenon was highlighted early in the 20th century, recent technological advances in diagnostics have led to the appreciation that many infections are far more complex than originally believed. Furthermore, it is apparent that although most treatments focus on the dominant bacterial species in an infection, other microbes, including commensals, can have a profound impact on both the response to therapy and virulence. Very little is known about the molecular mechanisms that underpin interactions between bacteria during such infections. Here, we discuss recent studies identifying and characterizing mechanisms of bacterial interaction and the biological processes they govern during certain diseases. We also highlight how possible strategies for targeting these interbacterial interactions may afford a route towards development of new therapies, with consequences for disease control.
    Original languageEnglish
    Pages (from-to)508-516
    Number of pages9
    JournalTrends in Microbiology
    Volume22
    Issue number9
    DOIs
    Publication statusPublished - Sep 2014

    Fingerprint Dive into the research topics of 'Polybacterial human disease: the ills of social networking'. Together they form a unique fingerprint.

    Cite this