Polydopamine‐Based Surface Functionalization of Watermelon Rind as a 3D Nanofibrous Cellulose Scaffold for Osteogenesis

Rezvaneh Banaeyan, Mohammad Nourany, Saadi Hosseini, Atena Galefi, Atefeh Alipour (Lead / Corresponding author), Mehdi Jahanfar, Peng Yuan Wang, Shahin Homaeigohar, Hosein Shahsavarani (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In this study, we investigated the osteogenic potential of a low cost, sustainable cellulosic scaffold made from decellularized water-melon rind (dWMR). The dWMR scaffold was later surface treated with polydopamine (PDA) to achieve a higher surface roughness and a protein adhesive, hydrophilic surface. The PDA coated dWMR scaffold was characterized through morphological, enzymatic activity and molecular analyses. The osteogenic differentiation of human mesenchymal stem cells (hMSCs) proved the osteoinductive potential of the dWMR scaffold. The PDA treatment supported the osteoinduction of hMSCs, as reflected in the raised expression level of the genes responsible for mineralization and formation of hydroxyapatite crystals compared to that for the dWMR.
Original languageEnglish
Pages (from-to)443-461
Number of pages19
JournalCellulose
Volume31
Issue number1
Early online date8 Dec 2023
DOIs
Publication statusPublished - Jan 2024

Keywords

  • Osteogenic differentiation
  • Plant- based scaffold
  • Polydopamine
  • Watermelon rind

ASJC Scopus subject areas

  • Polymers and Plastics

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