Polydopamine‐Based Surface Functionalization of Watermelon Rind as a 3D Nanofibrous Cellulose Scaffold for Osteogenesis

Rezvaneh Banaeyan; Mohammad Nourany; Saadi Hosseini; Atena Galefi; Atefeh Alipour; Mehdi  Jahanfar; Peng Yuan Wang; Shahin Homaeigohar; Hosein Shahsavarani

doi:10.1007/s10570-023-05611-z

Polydopamine‐Based Surface Functionalization of Watermelon Rind as a 3D Nanofibrous Cellulose Scaffold for Osteogenesis

Rezvaneh Banaeyan, Mohammad Nourany, Saadi Hosseini, Atena Galefi, Atefeh Alipour (Lead / Corresponding author), Mehdi Jahanfar, Peng Yuan Wang, Shahin Homaeigohar, Hosein Shahsavarani (Lead / Corresponding author)

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In this study, we investigated the osteogenic potential of a low cost, sustainable cellulosic scaffold made from decellularized water-melon rind (dWMR). The dWMR scaffold was later surface treated with polydopamine (PDA) to achieve a higher surface roughness and a protein adhesive, hydrophilic surface. The PDA coated dWMR scaffold was characterized through morphological, enzymatic activity and molecular analyses. The osteogenic differentiation of human mesenchymal stem cells (hMSCs) proved the osteoinductive potential of the dWMR scaffold. The PDA treatment supported the osteoinduction of hMSCs, as reflected in the raised expression level of the genes responsible for mineralization and formation of hydroxyapatite crystals compared to that for the dWMR.

Original language	English
Pages (from-to)	443-461
Number of pages	19
Journal	Cellulose
Volume	31
Issue number	1
Early online date	8 Dec 2023
DOIs	https://doi.org/10.1007/s10570-023-05611-z
Publication status	Published - Jan 2024

Keywords

Osteogenic differentiation
Plant- based scaffold
Polydopamine
Watermelon rind

ASJC Scopus subject areas

Polymers and Plastics

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10.1007/s10570-023-05611-z

Author accepted manuscriptAccepted author manuscript, 3.81 MBLicence: Other

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title = "Polydopamine‐Based Surface Functionalization of Watermelon Rind as a 3D Nanofibrous Cellulose Scaffold for Osteogenesis",

abstract = "In this study, we investigated the osteogenic potential of a low cost, sustainable cellulosic scaffold made from decellularized water-melon rind (dWMR). The dWMR scaffold was later surface treated with polydopamine (PDA) to achieve a higher surface roughness and a protein adhesive, hydrophilic surface. The PDA coated dWMR scaffold was characterized through morphological, enzymatic activity and molecular analyses. The osteogenic differentiation of human mesenchymal stem cells (hMSCs) proved the osteoinductive potential of the dWMR scaffold. The PDA treatment supported the osteoinduction of hMSCs, as reflected in the raised expression level of the genes responsible for mineralization and formation of hydroxyapatite crystals compared to that for the dWMR.",

keywords = "Osteogenic differentiation, Plant- based scaffold, Polydopamine, Watermelon rind",

author = "Rezvaneh Banaeyan and Mohammad Nourany and Saadi Hosseini and Atena Galefi and Atefeh Alipour and Mehdi Jahanfar and Wang, {Peng Yuan} and Shahin Homaeigohar and Hosein Shahsavarani",

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AU - Banaeyan, Rezvaneh

AU - Nourany, Mohammad

AU - Hosseini, Saadi

AU - Galefi, Atena

AU - Alipour, Atefeh

AU - Jahanfar, Mehdi

AU - Wang, Peng Yuan

AU - Homaeigohar, Shahin

AU - Shahsavarani, Hosein

PY - 2024/1

Y1 - 2024/1

N2 - In this study, we investigated the osteogenic potential of a low cost, sustainable cellulosic scaffold made from decellularized water-melon rind (dWMR). The dWMR scaffold was later surface treated with polydopamine (PDA) to achieve a higher surface roughness and a protein adhesive, hydrophilic surface. The PDA coated dWMR scaffold was characterized through morphological, enzymatic activity and molecular analyses. The osteogenic differentiation of human mesenchymal stem cells (hMSCs) proved the osteoinductive potential of the dWMR scaffold. The PDA treatment supported the osteoinduction of hMSCs, as reflected in the raised expression level of the genes responsible for mineralization and formation of hydroxyapatite crystals compared to that for the dWMR.

AB - In this study, we investigated the osteogenic potential of a low cost, sustainable cellulosic scaffold made from decellularized water-melon rind (dWMR). The dWMR scaffold was later surface treated with polydopamine (PDA) to achieve a higher surface roughness and a protein adhesive, hydrophilic surface. The PDA coated dWMR scaffold was characterized through morphological, enzymatic activity and molecular analyses. The osteogenic differentiation of human mesenchymal stem cells (hMSCs) proved the osteoinductive potential of the dWMR scaffold. The PDA treatment supported the osteoinduction of hMSCs, as reflected in the raised expression level of the genes responsible for mineralization and formation of hydroxyapatite crystals compared to that for the dWMR.

KW - Osteogenic differentiation

KW - Plant- based scaffold

KW - Polydopamine

KW - Watermelon rind

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U2 - 10.1007/s10570-023-05611-z

DO - 10.1007/s10570-023-05611-z

M3 - Article

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SP - 443

EP - 461

JO - Cellulose

JF - Cellulose

IS - 1

ER -

Polydopamine‐Based Surface Functionalization of Watermelon Rind as a 3D Nanofibrous Cellulose Scaffold for Osteogenesis

Abstract

Keywords

ASJC Scopus subject areas

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