Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

Christoph Sachse, Upinder Bhambra, Gillian Smith, Tracy J. Lightfoot, Jennifer H. Barrett, Jenna Scollay, R. Colin Garner, Alan R. Boobis, C. Roland Wolf, Nigel J. Gooderham, Colorectal Cancer Study Group

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    148 Citations (Scopus)

    Abstract

    Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.
    Original languageEnglish
    Pages (from-to)68-76
    Number of pages9
    JournalBritish Journal of Clinical Pharmacology
    Volume55
    Issue number1
    DOIs
    Publication statusPublished - 2003

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