Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

Christoph Sachse; Upinder Bhambra; Gillian Smith; Tracy J. Lightfoot; Jennifer H. Barrett; Jenna Scollay; R. Colin Garner; Alan R. Boobis; C. Roland Wolf; Nigel J. Gooderham; Colorectal Cancer Study Group

doi:10.1046/j.1365-2125.2003.01733.x

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

Christoph Sachse, Upinder Bhambra, Gillian Smith, Tracy J. Lightfoot, Jennifer H. Barrett, Jenna Scollay, R. Colin Garner, Alan R. Boobis, C. Roland Wolf, Nigel J. Gooderham, Colorectal Cancer Study Group

Research output: Contribution to journal › Article › peer-review

157 Citations (Scopus)

Abstract

Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.

Original language	English
Pages (from-to)	68-76
Number of pages	9
Journal	British Journal of Clinical Pharmacology
Volume	55
Issue number	1
DOIs	https://doi.org/10.1046/j.1365-2125.2003.01733.x
Publication status	Published - 2003

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Sachse, C., Bhambra, U., Smith, G., Lightfoot, T. J., Barrett, J. H., Scollay, J., Garner, R. C., Boobis, A. R., Wolf, C. R., Gooderham, N. J., & Colorectal Cancer Study Group (2003). Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism. British Journal of Clinical Pharmacology, 55(1), 68-76. https://doi.org/10.1046/j.1365-2125.2003.01733.x

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title = "Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism",

abstract = "Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.",

author = "Christoph Sachse and Upinder Bhambra and Gillian Smith and Lightfoot, {Tracy J.} and Barrett, {Jennifer H.} and Jenna Scollay and Garner, {R. Colin} and Boobis, {Alan R.} and Wolf, {C. Roland} and Gooderham, {Nigel J.} and {Colorectal Cancer Study Group}",

year = "2003",

doi = "10.1046/j.1365-2125.2003.01733.x",

language = "English",

volume = "55",

pages = "68--76",

journal = "British Journal of Clinical Pharmacology",

issn = "0306-5251",

publisher = "Wiley-Blackwell",

number = "1",

}

Sachse, C, Bhambra, U, Smith, G, Lightfoot, TJ, Barrett, JH, Scollay, J, Garner, RC, Boobis, AR, Wolf, CR, Gooderham, NJ & Colorectal Cancer Study Group 2003, 'Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism', British Journal of Clinical Pharmacology, vol. 55, no. 1, pp. 68-76. https://doi.org/10.1046/j.1365-2125.2003.01733.x

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism. / Sachse, Christoph; Bhambra, Upinder; Smith, Gillian et al.
In: British Journal of Clinical Pharmacology, Vol. 55, No. 1, 2003, p. 68-76.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls

T2 - allele frequencies, linkage disequilibrium and influence on caffeine metabolism

AU - Sachse, Christoph

AU - Bhambra, Upinder

AU - Smith, Gillian

AU - Lightfoot, Tracy J.

AU - Barrett, Jennifer H.

AU - Scollay, Jenna

AU - Garner, R. Colin

AU - Boobis, Alan R.

AU - Wolf, C. Roland

AU - Gooderham, Nigel J.

AU - Colorectal Cancer Study Group

PY - 2003

Y1 - 2003

N2 - Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.

AB - Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.

U2 - 10.1046/j.1365-2125.2003.01733.x

DO - 10.1046/j.1365-2125.2003.01733.x

M3 - Article

C2 - 12534642

SN - 0306-5251

VL - 55

SP - 68

EP - 76

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 1

ER -

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

Abstract

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