Polymorphisms of the angiotensin converting enzyme gene in early-onset and late-onset pre-eclampsia

Ramalingam Uma, Stewart J. Forsyth, Allan D. Struthers, Callum G. Fraser, Valerie Godfrey, Deirdre J. Murphy

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Objective. The aim of this study was to investigate differences in maternal and infant ACE genotypes in early-onset and later-onset pre-eclampsia/toxemia (PET).

    Methods. We conducted a case-control study of 22 cases of early-onset pre-eclampsia (before 34 weeks gestation), 38 cases of later-onset pre-eclampsia (after 34 weeks gestation), and 108 healthy controls delivered at term (38-40 weeks gestation) within a stable Caucasian population. Maternal venous blood and cord bloods were obtained for serum angiotensin converting enzyme (ACE) activity, ACE genotype, and acid-base status.

    Results. Mothers who developed early-onset PET were more likely to be homozygous for the deletion allele of the ACE genotype (DD) than mothers with late-onset PET or uncomplicated pregnancies (12/22 (55%) vs. 7/38 (18%) vs. 22/105 (21%), respectively; OR 2.96 [95% confidence intervals (CI) 1.37-6.31]. Infants of mothers with early-onset PET were more likely to be homozygous for the DD genotype than infants of mothers with late-onset PET or controls (7/19 (37%) vs. 9/36 (25%) vs. 11/78 (14%); OR 2.51 (95% CI 1.12-5.61). There were no differences in maternal or infant ACE activities in relation to onset of pre-eclampsia.

    Conclusions. Our findings suggest an association between the DD genotype of the ACE gene and early-onset but not later-onset pre-eclampsia which may give a partial explanation for the higher recurrence risk with early-onset pre-eclampsia.

    Original languageEnglish
    Pages (from-to)874-879
    Number of pages6
    JournalJournal of Maternal-Fetal & Neonatal Medicine
    Volume23
    Issue number8
    DOIs
    Publication statusPublished - Aug 2010

    Keywords

    • ACE genotype
    • early-onset pre-eclampsia
    • serum angiotensin converting enzyme
    • INSERTION-DELETION POLYMORPHISM
    • PREGNANCY-INDUCED HYPERTENSION
    • GESTATIONAL HYPERTENSION
    • ENDOTHELIAL DYSFUNCTION
    • RECURRENCE RISK
    • 1ST PREGNANCY
    • 2ND PREGNANCY
    • WOMEN
    • SYSTEM
    • OUTCOMES

    Cite this

    Uma, Ramalingam ; Forsyth, Stewart J. ; Struthers, Allan D. ; Fraser, Callum G. ; Godfrey, Valerie ; Murphy, Deirdre J. / Polymorphisms of the angiotensin converting enzyme gene in early-onset and late-onset pre-eclampsia. In: Journal of Maternal-Fetal & Neonatal Medicine. 2010 ; Vol. 23, No. 8. pp. 874-879.
    @article{e9916ac8f2a94db798b40aaa310739a4,
    title = "Polymorphisms of the angiotensin converting enzyme gene in early-onset and late-onset pre-eclampsia",
    abstract = "Objective. The aim of this study was to investigate differences in maternal and infant ACE genotypes in early-onset and later-onset pre-eclampsia/toxemia (PET).Methods. We conducted a case-control study of 22 cases of early-onset pre-eclampsia (before 34 weeks gestation), 38 cases of later-onset pre-eclampsia (after 34 weeks gestation), and 108 healthy controls delivered at term (38-40 weeks gestation) within a stable Caucasian population. Maternal venous blood and cord bloods were obtained for serum angiotensin converting enzyme (ACE) activity, ACE genotype, and acid-base status.Results. Mothers who developed early-onset PET were more likely to be homozygous for the deletion allele of the ACE genotype (DD) than mothers with late-onset PET or uncomplicated pregnancies (12/22 (55{\%}) vs. 7/38 (18{\%}) vs. 22/105 (21{\%}), respectively; OR 2.96 [95{\%} confidence intervals (CI) 1.37-6.31]. Infants of mothers with early-onset PET were more likely to be homozygous for the DD genotype than infants of mothers with late-onset PET or controls (7/19 (37{\%}) vs. 9/36 (25{\%}) vs. 11/78 (14{\%}); OR 2.51 (95{\%} CI 1.12-5.61). There were no differences in maternal or infant ACE activities in relation to onset of pre-eclampsia.Conclusions. Our findings suggest an association between the DD genotype of the ACE gene and early-onset but not later-onset pre-eclampsia which may give a partial explanation for the higher recurrence risk with early-onset pre-eclampsia.",
    keywords = "ACE genotype, early-onset pre-eclampsia, serum angiotensin converting enzyme, INSERTION-DELETION POLYMORPHISM, PREGNANCY-INDUCED HYPERTENSION, GESTATIONAL HYPERTENSION, ENDOTHELIAL DYSFUNCTION, RECURRENCE RISK, 1ST PREGNANCY, 2ND PREGNANCY, WOMEN, SYSTEM, OUTCOMES",
    author = "Ramalingam Uma and Forsyth, {Stewart J.} and Struthers, {Allan D.} and Fraser, {Callum G.} and Valerie Godfrey and Murphy, {Deirdre J.}",
    year = "2010",
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    doi = "10.3109/14767050903456667",
    language = "English",
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    Polymorphisms of the angiotensin converting enzyme gene in early-onset and late-onset pre-eclampsia. / Uma, Ramalingam; Forsyth, Stewart J.; Struthers, Allan D.; Fraser, Callum G.; Godfrey, Valerie; Murphy, Deirdre J.

    In: Journal of Maternal-Fetal & Neonatal Medicine, Vol. 23, No. 8, 08.2010, p. 874-879.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Polymorphisms of the angiotensin converting enzyme gene in early-onset and late-onset pre-eclampsia

    AU - Uma, Ramalingam

    AU - Forsyth, Stewart J.

    AU - Struthers, Allan D.

    AU - Fraser, Callum G.

    AU - Godfrey, Valerie

    AU - Murphy, Deirdre J.

    PY - 2010/8

    Y1 - 2010/8

    N2 - Objective. The aim of this study was to investigate differences in maternal and infant ACE genotypes in early-onset and later-onset pre-eclampsia/toxemia (PET).Methods. We conducted a case-control study of 22 cases of early-onset pre-eclampsia (before 34 weeks gestation), 38 cases of later-onset pre-eclampsia (after 34 weeks gestation), and 108 healthy controls delivered at term (38-40 weeks gestation) within a stable Caucasian population. Maternal venous blood and cord bloods were obtained for serum angiotensin converting enzyme (ACE) activity, ACE genotype, and acid-base status.Results. Mothers who developed early-onset PET were more likely to be homozygous for the deletion allele of the ACE genotype (DD) than mothers with late-onset PET or uncomplicated pregnancies (12/22 (55%) vs. 7/38 (18%) vs. 22/105 (21%), respectively; OR 2.96 [95% confidence intervals (CI) 1.37-6.31]. Infants of mothers with early-onset PET were more likely to be homozygous for the DD genotype than infants of mothers with late-onset PET or controls (7/19 (37%) vs. 9/36 (25%) vs. 11/78 (14%); OR 2.51 (95% CI 1.12-5.61). There were no differences in maternal or infant ACE activities in relation to onset of pre-eclampsia.Conclusions. Our findings suggest an association between the DD genotype of the ACE gene and early-onset but not later-onset pre-eclampsia which may give a partial explanation for the higher recurrence risk with early-onset pre-eclampsia.

    AB - Objective. The aim of this study was to investigate differences in maternal and infant ACE genotypes in early-onset and later-onset pre-eclampsia/toxemia (PET).Methods. We conducted a case-control study of 22 cases of early-onset pre-eclampsia (before 34 weeks gestation), 38 cases of later-onset pre-eclampsia (after 34 weeks gestation), and 108 healthy controls delivered at term (38-40 weeks gestation) within a stable Caucasian population. Maternal venous blood and cord bloods were obtained for serum angiotensin converting enzyme (ACE) activity, ACE genotype, and acid-base status.Results. Mothers who developed early-onset PET were more likely to be homozygous for the deletion allele of the ACE genotype (DD) than mothers with late-onset PET or uncomplicated pregnancies (12/22 (55%) vs. 7/38 (18%) vs. 22/105 (21%), respectively; OR 2.96 [95% confidence intervals (CI) 1.37-6.31]. Infants of mothers with early-onset PET were more likely to be homozygous for the DD genotype than infants of mothers with late-onset PET or controls (7/19 (37%) vs. 9/36 (25%) vs. 11/78 (14%); OR 2.51 (95% CI 1.12-5.61). There were no differences in maternal or infant ACE activities in relation to onset of pre-eclampsia.Conclusions. Our findings suggest an association between the DD genotype of the ACE gene and early-onset but not later-onset pre-eclampsia which may give a partial explanation for the higher recurrence risk with early-onset pre-eclampsia.

    KW - ACE genotype

    KW - early-onset pre-eclampsia

    KW - serum angiotensin converting enzyme

    KW - INSERTION-DELETION POLYMORPHISM

    KW - PREGNANCY-INDUCED HYPERTENSION

    KW - GESTATIONAL HYPERTENSION

    KW - ENDOTHELIAL DYSFUNCTION

    KW - RECURRENCE RISK

    KW - 1ST PREGNANCY

    KW - 2ND PREGNANCY

    KW - WOMEN

    KW - SYSTEM

    KW - OUTCOMES

    U2 - 10.3109/14767050903456667

    DO - 10.3109/14767050903456667

    M3 - Article

    VL - 23

    SP - 874

    EP - 879

    JO - Journal of Maternal-Fetal & Neonatal Medicine

    JF - Journal of Maternal-Fetal & Neonatal Medicine

    SN - 1476-7058

    IS - 8

    ER -