Polymorphisms of the angiotensin converting enzyme gene in early-onset and late-onset pre-eclampsia

Ramalingam Uma, Stewart J. Forsyth, Allan D. Struthers, Callum G. Fraser, Valerie Godfrey, Deirdre J. Murphy

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    Abstract

    Objective. The aim of this study was to investigate differences in maternal and infant ACE genotypes in early-onset and later-onset pre-eclampsia/toxemia (PET).

    Methods. We conducted a case-control study of 22 cases of early-onset pre-eclampsia (before 34 weeks gestation), 38 cases of later-onset pre-eclampsia (after 34 weeks gestation), and 108 healthy controls delivered at term (38-40 weeks gestation) within a stable Caucasian population. Maternal venous blood and cord bloods were obtained for serum angiotensin converting enzyme (ACE) activity, ACE genotype, and acid-base status.

    Results. Mothers who developed early-onset PET were more likely to be homozygous for the deletion allele of the ACE genotype (DD) than mothers with late-onset PET or uncomplicated pregnancies (12/22 (55%) vs. 7/38 (18%) vs. 22/105 (21%), respectively; OR 2.96 [95% confidence intervals (CI) 1.37-6.31]. Infants of mothers with early-onset PET were more likely to be homozygous for the DD genotype than infants of mothers with late-onset PET or controls (7/19 (37%) vs. 9/36 (25%) vs. 11/78 (14%); OR 2.51 (95% CI 1.12-5.61). There were no differences in maternal or infant ACE activities in relation to onset of pre-eclampsia.

    Conclusions. Our findings suggest an association between the DD genotype of the ACE gene and early-onset but not later-onset pre-eclampsia which may give a partial explanation for the higher recurrence risk with early-onset pre-eclampsia.

    Original languageEnglish
    Pages (from-to)874-879
    Number of pages6
    JournalJournal of Maternal-Fetal & Neonatal Medicine
    Volume23
    Issue number8
    DOIs
    Publication statusPublished - Aug 2010

    Keywords

    • ACE genotype
    • early-onset pre-eclampsia
    • serum angiotensin converting enzyme
    • INSERTION-DELETION POLYMORPHISM
    • PREGNANCY-INDUCED HYPERTENSION
    • GESTATIONAL HYPERTENSION
    • ENDOTHELIAL DYSFUNCTION
    • RECURRENCE RISK
    • 1ST PREGNANCY
    • 2ND PREGNANCY
    • WOMEN
    • SYSTEM
    • OUTCOMES

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