Polymorphisms of the angiotensin converting enzyme gene in relation to intrauterine growth restriction

Ramalingam Uma, J. Stewart Forsyth, Allan D. Struthers, Callum G. Fraser, Valerie Godfrey, Deirdre J. Murphy

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    The aim of this case-control study was to explore the relation between maternal and infant angiotensin converting enzyme (ACE) activity and its genotypes in uncomplicated term pregnancies (>= 37 weeks) and pregnancies with growth-restricted infants (birthweight at or below the 5th centile). Venous cord bloods and maternal venous samples were obtained for serum ACE activity and ACE genotype. Growth-restricted infants (<= 5th centile) were more likely to be of the DD genotype compared to appropriately grown infants (42 vs. 13%, p = 0.003). There was no significant difference in the frequency of the maternal DD genotype between the two groups (33 vs. 22%, p = 0.43) and similarly no significant differences in the maternal or fetal ACE activities. Within the intrauterine growth restriction (IUGR) group, infants of the DD genotype had higher ACE activity compared to appropriately grown infants (p = 0.03). In conclusion, the DD genotype of the ACE gene appears to be associated with fetal growth and may be a factor in the increased risk of adult onset chronic diseases among growth-restricted infants.

    Original languageEnglish
    Pages (from-to)1197-1201
    Number of pages5
    JournalActa Obstetricia et Gynecologica Scandinavica
    Volume89
    Issue number9
    DOIs
    Publication statusPublished - Sep 2010

    Keywords

    • Serum angiotensin converting enzyme
    • birth weight
    • ACE genotype
    • BIRTH-WEIGHT
    • INFANCY
    • SYSTEM

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