Poor cognitive ageing

Vulnerabilities, mechanisms and the impact of nutritional interventions

Sophie Miquel, Claire Champ, Jon Day, Esther Aarts, Ben A. Bahr, Martijntje Bakker, Diána Bánáti, Vittorio Calabrese, Tommy Cederholm, John Cryan, Louise Dye, Jonathan A. Farrimond, Aniko Korosi, Sophie Layé, Stuart Maudsley, Dragan Milenkovic, M. Hasan Mohajeri, John Sijben, Alina Solomon, Jeremy P.E. Spencer & 8 others Sandrine Thuret, Wim Vanden Berghe, David Vauzour, Bruno Vellas, Keith Wesnes, Peter Willatts, Raphael Wittenberg, Lucie Geurts

Research output: Contribution to journalReview article

9 Citations (Scopus)
93 Downloads (Pure)

Abstract

Background: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated.

Objectives: This review aims to summarise the current state of knowledge of vulnerabilities that predispose towards dysfunctional brain ageing, highlight potential protective mechanisms, and discuss dietary interventions that may be used as therapies. A special focus of this paper is on the impact of nutrition on neuroprotection and the underlying molecular mechanisms, and this focus reflects the discussions held during the 2nd workshop ‘Nutrition for the Ageing Brain: Functional Aspects and Mechanisms’ in Copenhagen in June 2016. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe).

Conclusion: Coupling studies of cognitive ageing with studies investigating the effect of nutrition and dietary interventions as strategies targeting specific mechanisms, such as neurogenesis, protein clearance, inflammation, and non-coding and microRNAs is of high value. Future research on the impact of nutrition on cognitive ageing will need to adopt a longitudinal approach and multimodal nutritional interventions will likely need to be imposed in early-life to observe significant impact in older age.

Original languageEnglish
Pages (from-to)40-55
Number of pages16
JournalAgeing Research Reviews
Volume42
Early online date15 Dec 2017
DOIs
Publication statusPublished - 1 Mar 2018

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Nutrition
Aging of materials
Brain
Biological Science Disciplines
Neurogenesis
Advisory Committees
MicroRNAs
Neurodegenerative Diseases
Cognition
Dementia
Diet
Inflammation
Education
Food
Cognitive Aging
Health
Nutrients
Proteins
Therapeutics

Keywords

  • Cognition
  • Cognitive decline
  • Neuro-inflammation
  • Neuroprotection
  • Plant-food bioactives
  • Preventive diet

Cite this

Miquel, S., Champ, C., Day, J., Aarts, E., Bahr, B. A., Bakker, M., ... Geurts, L. (2018). Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions. Ageing Research Reviews, 42, 40-55. https://doi.org/10.1016/j.arr.2017.12.004
Miquel, Sophie ; Champ, Claire ; Day, Jon ; Aarts, Esther ; Bahr, Ben A. ; Bakker, Martijntje ; Bánáti, Diána ; Calabrese, Vittorio ; Cederholm, Tommy ; Cryan, John ; Dye, Louise ; Farrimond, Jonathan A. ; Korosi, Aniko ; Layé, Sophie ; Maudsley, Stuart ; Milenkovic, Dragan ; Mohajeri, M. Hasan ; Sijben, John ; Solomon, Alina ; Spencer, Jeremy P.E. ; Thuret, Sandrine ; Vanden Berghe, Wim ; Vauzour, David ; Vellas, Bruno ; Wesnes, Keith ; Willatts, Peter ; Wittenberg, Raphael ; Geurts, Lucie. / Poor cognitive ageing : Vulnerabilities, mechanisms and the impact of nutritional interventions. In: Ageing Research Reviews. 2018 ; Vol. 42. pp. 40-55.
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title = "Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions",
abstract = "Background: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated.Objectives: This review aims to summarise the current state of knowledge of vulnerabilities that predispose towards dysfunctional brain ageing, highlight potential protective mechanisms, and discuss dietary interventions that may be used as therapies. A special focus of this paper is on the impact of nutrition on neuroprotection and the underlying molecular mechanisms, and this focus reflects the discussions held during the 2nd workshop ‘Nutrition for the Ageing Brain: Functional Aspects and Mechanisms’ in Copenhagen in June 2016. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe).Conclusion: Coupling studies of cognitive ageing with studies investigating the effect of nutrition and dietary interventions as strategies targeting specific mechanisms, such as neurogenesis, protein clearance, inflammation, and non-coding and microRNAs is of high value. Future research on the impact of nutrition on cognitive ageing will need to adopt a longitudinal approach and multimodal nutritional interventions will likely need to be imposed in early-life to observe significant impact in older age.",
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Miquel, S, Champ, C, Day, J, Aarts, E, Bahr, BA, Bakker, M, Bánáti, D, Calabrese, V, Cederholm, T, Cryan, J, Dye, L, Farrimond, JA, Korosi, A, Layé, S, Maudsley, S, Milenkovic, D, Mohajeri, MH, Sijben, J, Solomon, A, Spencer, JPE, Thuret, S, Vanden Berghe, W, Vauzour, D, Vellas, B, Wesnes, K, Willatts, P, Wittenberg, R & Geurts, L 2018, 'Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions', Ageing Research Reviews, vol. 42, pp. 40-55. https://doi.org/10.1016/j.arr.2017.12.004

Poor cognitive ageing : Vulnerabilities, mechanisms and the impact of nutritional interventions. / Miquel, Sophie; Champ, Claire; Day, Jon; Aarts, Esther; Bahr, Ben A.; Bakker, Martijntje; Bánáti, Diána; Calabrese, Vittorio; Cederholm, Tommy; Cryan, John; Dye, Louise; Farrimond, Jonathan A.; Korosi, Aniko; Layé, Sophie; Maudsley, Stuart; Milenkovic, Dragan; Mohajeri, M. Hasan; Sijben, John; Solomon, Alina; Spencer, Jeremy P.E.; Thuret, Sandrine; Vanden Berghe, Wim; Vauzour, David; Vellas, Bruno; Wesnes, Keith; Willatts, Peter; Wittenberg, Raphael; Geurts, Lucie (Lead / Corresponding author).

In: Ageing Research Reviews, Vol. 42, 01.03.2018, p. 40-55.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Poor cognitive ageing

T2 - Vulnerabilities, mechanisms and the impact of nutritional interventions

AU - Miquel, Sophie

AU - Champ, Claire

AU - Day, Jon

AU - Aarts, Esther

AU - Bahr, Ben A.

AU - Bakker, Martijntje

AU - Bánáti, Diána

AU - Calabrese, Vittorio

AU - Cederholm, Tommy

AU - Cryan, John

AU - Dye, Louise

AU - Farrimond, Jonathan A.

AU - Korosi, Aniko

AU - Layé, Sophie

AU - Maudsley, Stuart

AU - Milenkovic, Dragan

AU - Mohajeri, M. Hasan

AU - Sijben, John

AU - Solomon, Alina

AU - Spencer, Jeremy P.E.

AU - Thuret, Sandrine

AU - Vanden Berghe, Wim

AU - Vauzour, David

AU - Vellas, Bruno

AU - Wesnes, Keith

AU - Willatts, Peter

AU - Wittenberg, Raphael

AU - Geurts, Lucie

N1 - no funding info

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated.Objectives: This review aims to summarise the current state of knowledge of vulnerabilities that predispose towards dysfunctional brain ageing, highlight potential protective mechanisms, and discuss dietary interventions that may be used as therapies. A special focus of this paper is on the impact of nutrition on neuroprotection and the underlying molecular mechanisms, and this focus reflects the discussions held during the 2nd workshop ‘Nutrition for the Ageing Brain: Functional Aspects and Mechanisms’ in Copenhagen in June 2016. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe).Conclusion: Coupling studies of cognitive ageing with studies investigating the effect of nutrition and dietary interventions as strategies targeting specific mechanisms, such as neurogenesis, protein clearance, inflammation, and non-coding and microRNAs is of high value. Future research on the impact of nutrition on cognitive ageing will need to adopt a longitudinal approach and multimodal nutritional interventions will likely need to be imposed in early-life to observe significant impact in older age.

AB - Background: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated.Objectives: This review aims to summarise the current state of knowledge of vulnerabilities that predispose towards dysfunctional brain ageing, highlight potential protective mechanisms, and discuss dietary interventions that may be used as therapies. A special focus of this paper is on the impact of nutrition on neuroprotection and the underlying molecular mechanisms, and this focus reflects the discussions held during the 2nd workshop ‘Nutrition for the Ageing Brain: Functional Aspects and Mechanisms’ in Copenhagen in June 2016. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe).Conclusion: Coupling studies of cognitive ageing with studies investigating the effect of nutrition and dietary interventions as strategies targeting specific mechanisms, such as neurogenesis, protein clearance, inflammation, and non-coding and microRNAs is of high value. Future research on the impact of nutrition on cognitive ageing will need to adopt a longitudinal approach and multimodal nutritional interventions will likely need to be imposed in early-life to observe significant impact in older age.

KW - Cognition

KW - Cognitive decline

KW - Neuro-inflammation

KW - Neuroprotection

KW - Plant-food bioactives

KW - Preventive diet

U2 - 10.1016/j.arr.2017.12.004

DO - 10.1016/j.arr.2017.12.004

M3 - Review article

VL - 42

SP - 40

EP - 55

JO - Ageing Research Reviews

JF - Ageing Research Reviews

SN - 1568-1637

ER -