TY - JOUR
T1 - Poor cognitive ageing
T2 - Vulnerabilities, mechanisms and the impact of nutritional interventions
AU - Miquel, Sophie
AU - Champ, Claire
AU - Day, Jon
AU - Aarts, Esther
AU - Bahr, Ben A.
AU - Bakker, Martijntje
AU - Bánáti, Diána
AU - Calabrese, Vittorio
AU - Cederholm, Tommy
AU - Cryan, John
AU - Dye, Louise
AU - Farrimond, Jonathan A.
AU - Korosi, Aniko
AU - Layé, Sophie
AU - Maudsley, Stuart
AU - Milenkovic, Dragan
AU - Mohajeri, M. Hasan
AU - Sijben, John
AU - Solomon, Alina
AU - Spencer, Jeremy P.E.
AU - Thuret, Sandrine
AU - Vanden Berghe, Wim
AU - Vauzour, David
AU - Vellas, Bruno
AU - Wesnes, Keith
AU - Willatts, Peter
AU - Wittenberg, Raphael
AU - Geurts, Lucie
N1 - no funding info
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Background: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated.Objectives: This review aims to summarise the current state of knowledge of vulnerabilities that predispose towards dysfunctional brain ageing, highlight potential protective mechanisms, and discuss dietary interventions that may be used as therapies. A special focus of this paper is on the impact of nutrition on neuroprotection and the underlying molecular mechanisms, and this focus reflects the discussions held during the 2nd workshop ‘Nutrition for the Ageing Brain: Functional Aspects and Mechanisms’ in Copenhagen in June 2016. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe).Conclusion: Coupling studies of cognitive ageing with studies investigating the effect of nutrition and dietary interventions as strategies targeting specific mechanisms, such as neurogenesis, protein clearance, inflammation, and non-coding and microRNAs is of high value. Future research on the impact of nutrition on cognitive ageing will need to adopt a longitudinal approach and multimodal nutritional interventions will likely need to be imposed in early-life to observe significant impact in older age.
AB - Background: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated.Objectives: This review aims to summarise the current state of knowledge of vulnerabilities that predispose towards dysfunctional brain ageing, highlight potential protective mechanisms, and discuss dietary interventions that may be used as therapies. A special focus of this paper is on the impact of nutrition on neuroprotection and the underlying molecular mechanisms, and this focus reflects the discussions held during the 2nd workshop ‘Nutrition for the Ageing Brain: Functional Aspects and Mechanisms’ in Copenhagen in June 2016. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe).Conclusion: Coupling studies of cognitive ageing with studies investigating the effect of nutrition and dietary interventions as strategies targeting specific mechanisms, such as neurogenesis, protein clearance, inflammation, and non-coding and microRNAs is of high value. Future research on the impact of nutrition on cognitive ageing will need to adopt a longitudinal approach and multimodal nutritional interventions will likely need to be imposed in early-life to observe significant impact in older age.
KW - Cognition
KW - Cognitive decline
KW - Neuro-inflammation
KW - Neuroprotection
KW - Plant-food bioactives
KW - Preventive diet
U2 - 10.1016/j.arr.2017.12.004
DO - 10.1016/j.arr.2017.12.004
M3 - Review article
C2 - 29248758
AN - SCOPUS:85038078160
SN - 1568-1637
VL - 42
SP - 40
EP - 55
JO - Ageing Research Reviews
JF - Ageing Research Reviews
ER -