Projects per year
The name "eukaryote" is derived from Greek, meaning "true kernel", and describes the domain of organisms whose cells have a nucleus. The nucleus is thus the defining feature of eukaryotes and distinguishes them from prokaryotes (Archaea and Bacteria), whose cells lack nuclei. Despite this, we discuss the intriguing possibility that organisms on the path from the first eukaryotic common ancestor to the last common ancestor of all eukaryotes did not possess a nucleus at all-at least not in a form we would recognize today-and that the nucleus in fact arrived relatively late in the evolution of eukaryotes. The clues to this alternative evolutionary path lie, most of all, in recent discoveries concerning the structure of the nuclear pore complex. We discuss the evidence for such a possibility and how this impacts our views of eukaryote origins and how eukaryotes have diversified subsequent to their last common ancestor.
|Number of pages||11|
|Publication status||Published - 3 Apr 2019|
- molecular evolution
- nuclear pore complex
- vesicle coats
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
FingerprintDive into the research topics of 'Pore timing: the evolutionary origins of the nucleus and nuclear pore complex'. Together they form a unique fingerprint.
A Systems Approach for Understanding Cell Surface Dynamics in Trypanosomes (Investigator Award)
1/10/17 → 31/03/24
Control of Gene Expression in Trypanosoes: Defining the Nuclear Lamina
1/07/16 → 29/02/20