Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents

Medicine & Life Sciences

• microsomal glutathione S-transferase-I 100%
• Cyclooxygenase 2 51%
• Prostaglandins E 50%
• Dinoprostone 48%
• 2-tert-butylhydroquinone 41%
• Colorectal Neoplasms 39%
• Xenobiotics 27%
• Colon 26%
• beta-Naphthoflavone 24%
• Antioxidants 18%
• indolo(3,2-b)carbazole 17%
• Neoplasms 15%
• Carcinogenesis 12%
• Piroxicam 11%
• Carcinoma 10%
• Genetic Enhancer Elements 10%
• 5' Flanking Region 9%
• Messenger RNA 9%
• Transgenes 8%
• Reporter Genes 8%
• Interleukin-1beta 7%
• Transfection 7%
• Transcription Factors 6%
• Anti-Inflammatory Agents 6%
• Up-Regulation 5%
• Down-Regulation 5%
• Cell Line 4%
• Pharmaceutical Preparations 3%

Chemical Compounds

• Cancer Chemopreventive 76%
• Prostaglandin E2 66%
• Prostaglandin E 64%
• Glutathione 44%
• Biosynthesis 41%
• Xenobiotic Agent 28%
• Beta-Naphthoflavone 26%
• Antioxidant Agent 18%
• Chemopreventive 11%
• Piroxicam 11%
• Enhancer 9%
• Inducer 9%
• Nonsteroid Antiinflammatory Agent 9%
• Carbazole 8%
• Antagonist 7%