Positron emission tomography and histopathology in Creutzfeldt-Jakob disease

S. Goldman, A. Liard, J. Flament-Durand, A. Luxen, L.M. Bidaut, E. Stanus, J. Hildebrand, S. Przedborski

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)


    We studied a 62-year-old man with Creutzfeldt-Jakob disease (CJD), using positron emission tomography (PET) and (F)-2-fluoro-2-deoxy-D-glucose (FDG). Glucose metabolism was heterogeneously decreased throughout the brain. At autopsy, regional distributions of spongiosis, astrogliosis, and neuronal loss correlated with premortem regional metabolic deficits. These results suggest that PET with FDG may provide metabolic regional markers for CJD neuropathology.
    Original languageEnglish
    Pages (from-to)1828-1830
    Number of pages3
    Issue number9
    Publication statusPublished - 1 Jan 1993


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