Possible role for arginine-containing toothpastes in managing dentine hypersensitivity

    Research output: Contribution to journalComment/debate

    2 Citations (Scopus)

    Abstract

    DATA SOURCES: The Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and LILACS databases were searched. Reference lists of eligible studies and systematic reviews were cross-checked to identify additional studies.

    STUDY SELECTION: Randomised and controlled clinical trials conducted in adults with at least two hypersensitive teeth confirmed by evaporative stimulus or tactile hypersensitivity assessment comparing arginine-containing desensitising toothpastes to non-arginine-containing control toothpastes were included.

    DATA EXTRACTION AND SYNTHESIS: Data abstraction and risk of bias assessment were conducted independently by two reviewers and a qualitative summary presented.

    RESULTS: Two randomised trials met the criteria; both showed a positive effect on dentine hypersensitivity in response to tactile and air-blast stimuli. No subjective measures of sensitivity were reported.

    CONCLUSIONS: Data identified indicate a potential role for arginine-containing toothpastes in managing dentine hypersensitivity. However, this conclusion is based on small sample sizes and the studies identified did not follow patients up in the medium to long term. The authors recommend that there is a need for well-designed RCTs to be conducted prior to any definitive recommendations being made.

    Original languageEnglish
    Pages (from-to)44-45
    Number of pages2
    JournalEvidence-Based Dentistry
    Volume14
    Issue number2
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Dentin Sensitivity
    Toothpastes
    Arginine
    Touch
    Sample Size
    Tooth
    Hypersensitivity
    Randomized Controlled Trials
    Air
    Databases

    Keywords

    • Arginine
    • Dentin Desensitizing Agents
    • Dentin Sensitivity
    • Humans
    • Toothpastes

    Cite this

    @article{b943cafe8fdf432fa1786248e9b64ed6,
    title = "Possible role for arginine-containing toothpastes in managing dentine hypersensitivity",
    abstract = "DATA SOURCES: The Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and LILACS databases were searched. Reference lists of eligible studies and systematic reviews were cross-checked to identify additional studies.STUDY SELECTION: Randomised and controlled clinical trials conducted in adults with at least two hypersensitive teeth confirmed by evaporative stimulus or tactile hypersensitivity assessment comparing arginine-containing desensitising toothpastes to non-arginine-containing control toothpastes were included.DATA EXTRACTION AND SYNTHESIS: Data abstraction and risk of bias assessment were conducted independently by two reviewers and a qualitative summary presented.RESULTS: Two randomised trials met the criteria; both showed a positive effect on dentine hypersensitivity in response to tactile and air-blast stimuli. No subjective measures of sensitivity were reported.CONCLUSIONS: Data identified indicate a potential role for arginine-containing toothpastes in managing dentine hypersensitivity. However, this conclusion is based on small sample sizes and the studies identified did not follow patients up in the medium to long term. The authors recommend that there is a need for well-designed RCTs to be conducted prior to any definitive recommendations being made.",
    keywords = "Arginine, Dentin Desensitizing Agents, Dentin Sensitivity, Humans, Toothpastes",
    author = "Carson, {Susan J}",
    year = "2013",
    doi = "10.1038/sj.ebd.6400930",
    language = "English",
    volume = "14",
    pages = "44--45",
    journal = "Evidence-Based Dentistry",
    issn = "1462-0049",
    publisher = "Nature Publishing Group",
    number = "2",

    }

    Possible role for arginine-containing toothpastes in managing dentine hypersensitivity. / Carson, Susan J.

    In: Evidence-Based Dentistry, Vol. 14, No. 2, 2013, p. 44-45.

    Research output: Contribution to journalComment/debate

    TY - JOUR

    T1 - Possible role for arginine-containing toothpastes in managing dentine hypersensitivity

    AU - Carson, Susan J

    PY - 2013

    Y1 - 2013

    N2 - DATA SOURCES: The Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and LILACS databases were searched. Reference lists of eligible studies and systematic reviews were cross-checked to identify additional studies.STUDY SELECTION: Randomised and controlled clinical trials conducted in adults with at least two hypersensitive teeth confirmed by evaporative stimulus or tactile hypersensitivity assessment comparing arginine-containing desensitising toothpastes to non-arginine-containing control toothpastes were included.DATA EXTRACTION AND SYNTHESIS: Data abstraction and risk of bias assessment were conducted independently by two reviewers and a qualitative summary presented.RESULTS: Two randomised trials met the criteria; both showed a positive effect on dentine hypersensitivity in response to tactile and air-blast stimuli. No subjective measures of sensitivity were reported.CONCLUSIONS: Data identified indicate a potential role for arginine-containing toothpastes in managing dentine hypersensitivity. However, this conclusion is based on small sample sizes and the studies identified did not follow patients up in the medium to long term. The authors recommend that there is a need for well-designed RCTs to be conducted prior to any definitive recommendations being made.

    AB - DATA SOURCES: The Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and LILACS databases were searched. Reference lists of eligible studies and systematic reviews were cross-checked to identify additional studies.STUDY SELECTION: Randomised and controlled clinical trials conducted in adults with at least two hypersensitive teeth confirmed by evaporative stimulus or tactile hypersensitivity assessment comparing arginine-containing desensitising toothpastes to non-arginine-containing control toothpastes were included.DATA EXTRACTION AND SYNTHESIS: Data abstraction and risk of bias assessment were conducted independently by two reviewers and a qualitative summary presented.RESULTS: Two randomised trials met the criteria; both showed a positive effect on dentine hypersensitivity in response to tactile and air-blast stimuli. No subjective measures of sensitivity were reported.CONCLUSIONS: Data identified indicate a potential role for arginine-containing toothpastes in managing dentine hypersensitivity. However, this conclusion is based on small sample sizes and the studies identified did not follow patients up in the medium to long term. The authors recommend that there is a need for well-designed RCTs to be conducted prior to any definitive recommendations being made.

    KW - Arginine

    KW - Dentin Desensitizing Agents

    KW - Dentin Sensitivity

    KW - Humans

    KW - Toothpastes

    U2 - 10.1038/sj.ebd.6400930

    DO - 10.1038/sj.ebd.6400930

    M3 - Comment/debate

    VL - 14

    SP - 44

    EP - 45

    JO - Evidence-Based Dentistry

    JF - Evidence-Based Dentistry

    SN - 1462-0049

    IS - 2

    ER -