Post-exposure prophylaxis following occupational exposure to HIV and hepatitis B: An analysis of a 12-year record in a Nigerian tertiary hospital

Salisu Abubakar, Garba Iliyasu, Farouq Muhammad Dayyab, Salisu Inuwa, Rabiu Alhassan Tudun Wada, Nasiru Magaji Sadiq, Muktar Ahmed Gadanya, Abdulrahman Abba Sheshe, Mohammad Sani Mijinyawa, Abdulrazaq Garba Habib

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Background:
    Healthcare workers (HCWs) have an increased risk of occupational exposure to blood-borne pathogens.

    Aims/objectives:
    We aim to examine the utilisation and outcome of post-exposure prophylaxis (PEP) for both HIV and hepatitis B (HBV) among HCWs.

    Methods:
    This was a retrospective study conducted in a tertiary hospital in North-Western Nigeria. We reviewed data on HIV or HBV PEP given to HCWs between 2004 and 2016.

    Results:
    A total of 115 HCWs presented for PEP during the study period. Intern doctors were the most exposed group (40/115; 34.8%). There were 86/115 (74.8%) needle stick exposures. While 53/115 (46.1%) of the sources of exposure were HIV-positive, 9/115(7.83%) were HBV-positive. Zidovudine-based regimen (40/70) was the most commonly prescribed. No seroconversion occurred among those that completed PEP treatment and follow-up.

    Discussion:
    No seroconversion occurred among those that received either or both HIV and HBV PEP and completed PEP treatment.
    Original languageEnglish
    Pages (from-to)184-189
    Number of pages6
    JournalJournal of Infection Prevention
    Volume19
    Issue number4
    Early online date17 Dec 2017
    DOIs
    Publication statusPublished - 2018

    Keywords

    • Human immunodeficiency virus (HIV)
    • Infection control
    • Vaccination

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