Post-mortem stability and redistribution of carbohydrate-deficient transferrin (CDT)

Juha Rainio, Giorgia De Paoli, Henrik Druid, Riitta Kauppila, Fabio De Giorgio, Federica Bortolotti, Franco Tagliaro

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    16 Citations (Scopus)

    Abstract

    Post-mortem diagnosis of chronic alcohol abuse is a challenge for forensic experts due to the lack of pathognomonic morphological findings and often also inadequate background information. Objective methods demonstrating chronic excessive alcohol consumption would therefore be a useful tool for forensic pathologists. In clinical practice, several markers of chronic alcohol abuse have recently been introduced, among which carbohydrate-deficient transferrin (CDT) is the most accepted, but the use of these markers in autopsy has not yet been established. We examined post-mortem stability and possible post-mortem redistribution of CDT and compared two analytical methods, capillary zone electrophoresis and high-performance liquid chromatography. According to our results, CDT remains stable for an appreciable time after death. The results further indicate that CDT is not subject to major post-mortem redistribution. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)161-165
    Number of pages5
    JournalForensic Science International
    Volume174
    Issue number2-3
    DOIs
    Publication statusPublished - 30 Jan 2008

    Keywords

    • Carbohydrate-deficient transferrin
    • Chronic alcohol abuse
    • Autopsy
    • Post-mortem diagnosis
    • Capillary zone electrophoresis
    • High-performance liquid chromatography
    • Acid ethyl-esters
    • Alcohol consumption
    • Vitreous-humor
    • Social drinkers
    • Glucuronide
    • Markers
    • Blood
    • Hair
    • Tissues

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