Abstract
Nur77 is a nuclear orphan receptor that has been implicated in both cell survival and apoptosis. With the exception of T-cells, translocation of Nur77 to the cytoplasm promotes cell death, while its retention in the nucleus promotes survival and proliferation. Nur77 appears to be a true orphan receptor, indicating that its activity must be controlled by ligand-independent mechanisms. Here, we discuss the role of phosphorylation in the regulation of Nur77.
Original language | English |
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Pages (from-to) | 1107-1109 |
Number of pages | 3 |
Journal | Biochemical Society Transactions |
Volume | 34 |
Issue number | 6 |
Early online date | 25 Oct 2006 |
DOIs | |
Publication status | Published - Dec 2006 |
Keywords
- Cell survival
- Nuclear orphan receptor
- Nur77
- Phosphorylation
- Post-translational control
ASJC Scopus subject areas
- Biochemistry