Post-translational control of Nur77

A. D. Wingate, J. S.C. Arthur

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Nur77 is a nuclear orphan receptor that has been implicated in both cell survival and apoptosis. With the exception of T-cells, translocation of Nur77 to the cytoplasm promotes cell death, while its retention in the nucleus promotes survival and proliferation. Nur77 appears to be a true orphan receptor, indicating that its activity must be controlled by ligand-independent mechanisms. Here, we discuss the role of phosphorylation in the regulation of Nur77.

Original languageEnglish
Pages (from-to)1107-1109
Number of pages3
JournalBiochemical Society Transactions
Volume34
Issue number6
Early online date25 Oct 2006
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Cell survival
  • Nuclear orphan receptor
  • Nur77
  • Phosphorylation
  • Post-translational control

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