Post-translational control of Nur77

A. D. Wingate; J. S.C. Arthur

doi:10.1042/BST0341107

Post-translational control of Nur77

A. D. Wingate, J. S.C. Arthur

Cell Signalling and Immunology

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Nur77 is a nuclear orphan receptor that has been implicated in both cell survival and apoptosis. With the exception of T-cells, translocation of Nur77 to the cytoplasm promotes cell death, while its retention in the nucleus promotes survival and proliferation. Nur77 appears to be a true orphan receptor, indicating that its activity must be controlled by ligand-independent mechanisms. Here, we discuss the role of phosphorylation in the regulation of Nur77.

Original language	English
Pages (from-to)	1107-1109
Number of pages	3
Journal	Biochemical Society Transactions
Volume	34
Issue number	6
Early online date	25 Oct 2006
DOIs	https://doi.org/10.1042/BST0341107
Publication status	Published - Dec 2006

Keywords

Cell survival
Nuclear orphan receptor
Nur77
Phosphorylation
Post-translational control

ASJC Scopus subject areas

Biochemistry

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10.1042/BST0341107

Cite this

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abstract = "Nur77 is a nuclear orphan receptor that has been implicated in both cell survival and apoptosis. With the exception of T-cells, translocation of Nur77 to the cytoplasm promotes cell death, while its retention in the nucleus promotes survival and proliferation. Nur77 appears to be a true orphan receptor, indicating that its activity must be controlled by ligand-independent mechanisms. Here, we discuss the role of phosphorylation in the regulation of Nur77.",

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AB - Nur77 is a nuclear orphan receptor that has been implicated in both cell survival and apoptosis. With the exception of T-cells, translocation of Nur77 to the cytoplasm promotes cell death, while its retention in the nucleus promotes survival and proliferation. Nur77 appears to be a true orphan receptor, indicating that its activity must be controlled by ligand-independent mechanisms. Here, we discuss the role of phosphorylation in the regulation of Nur77.

KW - Cell survival

KW - Nuclear orphan receptor

KW - Nur77

KW - Phosphorylation

KW - Post-translational control

UR - https://www.scopus.com/pages/publications/34248652976

U2 - 10.1042/BST0341107

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JF - Biochemical Society Transactions

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ER -

Post-translational control of Nur77

Abstract

Keywords

ASJC Scopus subject areas

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