Post-translational modification by SUMO

Zara Hannoun, Sebastian Greenhough, Ellis Jaffray, Ronald T. Hay, David C. Hay

    Research output: Contribution to journalReview articlepeer-review

    104 Citations (Scopus)

    Abstract

    Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle regulation, gene transcription, differentiation and cellular localisation. Therefore, understanding the role of SUMOylation in cell biology may allow the development of more efficient models, important in streamlining the drug discovery process. This review will focus on protein SUMOylation and its role in stem cell and somatic cell biology. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)288-293
    Number of pages6
    JournalToxicology
    Volume278
    Issue number3
    DOIs
    Publication statusPublished - 30 Dec 2010

    Keywords

    • Post-translational modification
    • SUMO
    • Cell biology
    • UBIQUITIN-LIKE PROTEIN
    • HEPATOCYTE DIFFERENTIATION
    • MITOCHONDRIAL MORPHOLOGY
    • MAMMALIAN EMBRYO
    • STEM-CELLS
    • SUMOYLATION
    • NUCLEAR
    • PHOSPHORYLATION
    • ENDODERM
    • BINDING

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