Post-translational modification by SUMO

Zara Hannoun; Sebastian Greenhough; Ellis Jaffray; Ronald T. Hay; David C. Hay

doi:10.1016/j.tox.2010.07.013

Post-translational modification by SUMO

Zara Hannoun, Sebastian Greenhough, Ellis Jaffray, Ronald T. Hay, David C. Hay

Research output: Contribution to journal › Review article › peer-review

104 Citations (Scopus)

Abstract

Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle regulation, gene transcription, differentiation and cellular localisation. Therefore, understanding the role of SUMOylation in cell biology may allow the development of more efficient models, important in streamlining the drug discovery process. This review will focus on protein SUMOylation and its role in stem cell and somatic cell biology. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	288-293
Number of pages	6
Journal	Toxicology
Volume	278
Issue number	3
DOIs	https://doi.org/10.1016/j.tox.2010.07.013
Publication status	Published - 30 Dec 2010

Keywords

Post-translational modification
SUMO
Cell biology
UBIQUITIN-LIKE PROTEIN
HEPATOCYTE DIFFERENTIATION
MITOCHONDRIAL MORPHOLOGY
MAMMALIAN EMBRYO
STEM-CELLS
SUMOYLATION
NUCLEAR
PHOSPHORYLATION
ENDODERM
BINDING

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10.1016/j.tox.2010.07.013

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title = "Post-translational modification by SUMO",

abstract = "Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle regulation, gene transcription, differentiation and cellular localisation. Therefore, understanding the role of SUMOylation in cell biology may allow the development of more efficient models, important in streamlining the drug discovery process. This review will focus on protein SUMOylation and its role in stem cell and somatic cell biology. (C) 2010 Elsevier Ireland Ltd. All rights reserved.",

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author = "Zara Hannoun and Sebastian Greenhough and Ellis Jaffray and Hay, {Ronald T.} and Hay, {David C.}",

year = "2010",

month = dec,

day = "30",

doi = "10.1016/j.tox.2010.07.013",

language = "English",

volume = "278",

pages = "288--293",

journal = "Toxicology",

issn = "0300-483X",

publisher = "Elsevier",

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TY - JOUR

T1 - Post-translational modification by SUMO

AU - Hannoun, Zara

AU - Greenhough, Sebastian

AU - Jaffray, Ellis

AU - Hay, Ronald T.

AU - Hay, David C.

PY - 2010/12/30

Y1 - 2010/12/30

N2 - Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle regulation, gene transcription, differentiation and cellular localisation. Therefore, understanding the role of SUMOylation in cell biology may allow the development of more efficient models, important in streamlining the drug discovery process. This review will focus on protein SUMOylation and its role in stem cell and somatic cell biology. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

AB - Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle regulation, gene transcription, differentiation and cellular localisation. Therefore, understanding the role of SUMOylation in cell biology may allow the development of more efficient models, important in streamlining the drug discovery process. This review will focus on protein SUMOylation and its role in stem cell and somatic cell biology. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

KW - Post-translational modification

KW - SUMO

KW - Cell biology

KW - UBIQUITIN-LIKE PROTEIN

KW - HEPATOCYTE DIFFERENTIATION

KW - MITOCHONDRIAL MORPHOLOGY

KW - MAMMALIAN EMBRYO

KW - STEM-CELLS

KW - SUMOYLATION

KW - NUCLEAR

KW - PHOSPHORYLATION

KW - ENDODERM

KW - BINDING

U2 - 10.1016/j.tox.2010.07.013

DO - 10.1016/j.tox.2010.07.013

M3 - Review article

C2 - 20674646

SN - 0300-483X

VL - 278

SP - 288

EP - 293

JO - Toxicology

JF - Toxicology

IS - 3

ER -

Post-translational modification by SUMO

Abstract

Keywords

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