Postherpetic Neuralgia: From Preclinical Models to the Clinic

Ada Delaney, Lesley A. Colvin, Marie T. Fallon, Robert G. Dalziel, Rory Mitchell, Susan M. Fleetwood-Walker (Lead / Corresponding author)

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Postherpetic neuralgia (PHN), a common complication of herpes zoster, which results from reactivation of varicella zoster virus, is a challenging neuropathic pain syndrome. The incidence and severity of herpes zoster and PHN increases with immune impairment or age and may become a greater burden both in terms of health economics and individual suffering. A clearer understanding of the underlying mechanisms of this disease and translation of preclinical outcomes to the clinic may lead to more efficacious treatment options. Here we give an overview of recent findings from preclinical models and clinical research on PHN.

Original languageEnglish
Pages (from-to)630-637
Number of pages8
JournalNeurotherapeutics
Volume6
Issue number4
DOIs
Publication statusPublished - Oct 2009

Keywords

  • analgesia
  • animal model
  • chronic pain
  • herpes zoster
  • Postherpetic neuralgia
  • varicella zoster virus

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    Delaney, A., Colvin, L. A., Fallon, M. T., Dalziel, R. G., Mitchell, R., & Fleetwood-Walker, S. M. (2009). Postherpetic Neuralgia: From Preclinical Models to the Clinic. Neurotherapeutics, 6(4), 630-637. https://doi.org/10.1016/j.nurt.2009.07.005