In the twentieth century many chemical substances, now known as the NSAIDs, Survey or NSAIDs, were developed with the same anti-inflammatory, analgesic and antipyretic effects of aspirin. The introduction a few years ago of injectable preparations of the NSAIDs ketorolac, diclofenac, ketoprofen, and tenoxicam delivered perioperative analgesia free from opioid disadvantages of respiratory depression, sedation, nausea and vomiting, gastrointestinal stasis, or abuse potential. Extensive clinical investigation and use of NSAIDs have confirmed that they are effective postoperative analgesics, although significant contraindications and adverse effects limit this use.
|Title of host publication||Encyclopedia of Pain|
|Editors||Gerald F. Gebhart, Robert F. Schmidt|
|Publication status||Published - 2013|