PP1 Phosphatase complexes

Undruggable No Longer

Paola Vagnarelli (Lead / Corresponding author), Dario R. Alessi (Lead / Corresponding author)

Research output: Contribution to journalArticle

7 Downloads (Pure)

Abstract

The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease. The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.

Original languageEnglish
Pages (from-to)1049-1051
Number of pages3
JournalCell
Volume174
Issue number5
Early online date23 Aug 2018
DOIs
Publication statusPublished - 23 Aug 2018

Fingerprint

Phosphoprotein Phosphatases
Huntington Disease
Phosphoric Monoester Hydrolases
Phosphotransferases
Phosphorylation
Pharmacology
Threonine
Serine
Identification (control systems)

Cite this

Vagnarelli, Paola ; Alessi, Dario R. / PP1 Phosphatase complexes : Undruggable No Longer. In: Cell. 2018 ; Vol. 174, No. 5. pp. 1049-1051.
@article{04febf651788455d932506c42c06fd68,
title = "PP1 Phosphatase complexes: Undruggable No Longer",
abstract = "The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease. The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.",
author = "Paola Vagnarelli and Alessi, {Dario R.}",
note = "Commissioned piece.",
year = "2018",
month = "8",
day = "23",
doi = "10.1016/j.cell.2018.08.007",
language = "English",
volume = "174",
pages = "1049--1051",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier",
number = "5",

}

PP1 Phosphatase complexes : Undruggable No Longer. / Vagnarelli, Paola (Lead / Corresponding author); Alessi, Dario R. (Lead / Corresponding author).

In: Cell, Vol. 174, No. 5, 23.08.2018, p. 1049-1051.

Research output: Contribution to journalArticle

TY - JOUR

T1 - PP1 Phosphatase complexes

T2 - Undruggable No Longer

AU - Vagnarelli, Paola

AU - Alessi, Dario R.

N1 - Commissioned piece.

PY - 2018/8/23

Y1 - 2018/8/23

N2 - The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease. The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.

AB - The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease. The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.

U2 - 10.1016/j.cell.2018.08.007

DO - 10.1016/j.cell.2018.08.007

M3 - Article

VL - 174

SP - 1049

EP - 1051

JO - Cell

JF - Cell

SN - 0092-8674

IS - 5

ER -