Abstract
The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease. The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.
Original language | English |
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Pages (from-to) | 1049-1051 |
Number of pages | 3 |
Journal | Cell |
Volume | 174 |
Issue number | 5 |
Early online date | 23 Aug 2018 |
DOIs | |
Publication status | Published - 23 Aug 2018 |
ASJC Scopus subject areas
- General Biochemistry,Genetics and Molecular Biology