PP1 Phosphatase complexes: Undruggable No Longer

Paola Vagnarelli (Lead / Corresponding author), Dario R. Alessi (Lead / Corresponding author)

Research output: Contribution to journalArticle

4 Citations (Scopus)
98 Downloads (Pure)

Abstract

The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease. The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.

Original languageEnglish
Pages (from-to)1049-1051
Number of pages3
JournalCell
Volume174
Issue number5
Early online date23 Aug 2018
DOIs
Publication statusPublished - 23 Aug 2018

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